New “Smart” Implant Coatings Warn of Early Failure and Resist Infections

Researchers from the University of Illinois Urbana-Champaign have recently developed innovative “smart” coatings for orthopedic surgical implants. These coatings have the ability to monitor stress on the implants, providing early detection of potential implant failures. Furthermore, they can combat harmful bacteria that may cause infections. Inspired by the wings of dragonflies and cicadas, the smart coatings integrate flexible sensors with a nanostructured antibacterial surface.

In a new study in the journal <span class="glossaryLink" aria-describedby="tt" data-cmtooltip="

” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>Science Advances, a multidisciplinary team of researchers found the coatings prevented infection in live mice and mapped strain in commercial implants applied to sheep spines to warn of various implant or healing failures.

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“This is a combination of bio-inspired nanomaterial design with flexible electronics to battle a complicated, long-term biomedical problem,” said study leader Qing Cao, a U. of I. professor of materials science and engineering.

Both infection and device failure are major problems with orthopedic implants, each affecting up to 10% of patients, Cao said. Several approaches to fighting infection have been attempted, but all have severe limitations, he said: Biofilms can still form on water-repelling surfaces, and coatings laden with antibiotic chemicals or drugs run out in a span of months and have toxic effects on the surrounding tissue with little efficacy against drug-resistant strains of bacterial pathogens.

Taking inspiration from the naturally antibacterial wings of cicadas and dragonflies, the Illinois team created a thin foil patterned with <span class="glossaryLink" aria-describedby="tt" data-cmtooltip="

” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>nanoscale pillars like those found on the insects’ wings. When a bacterial cell attempts to bind to the foil, the pillars puncture the cell wall, killing it.@media(min-width:0px){#div-gpt-ad-scitechdaily_com-medrectangle-4-0-asloaded{max-width:580px!important;max-height:400px!important}}

“Using a mechanical approach to killing bacteria allowed us to bypass a lot of the problems with chemical approaches, while still giving us the flexibility needed to apply the coating to implant surfaces,” said pathobiology professor Gee Lau, a coauthor of the study.

On the back side of the nanostructured foil, where it contacts the implant device, the researchers integrated arrays of highly sensitive, flexible electronic sensors to monitor strain. This could help physicians watch the healing progress of individual patients, guide their rehabilitation to shorten the recovery time and minimize risks, and repair or replace devices before they hit the point of failure, the researchers said.

The engineering group then teamed up with veterinary clinical medicine professor Annette McCoy to test their prototype devices. They implanted the foils in live mice and monitored them for any sign of infection, even when bacteria were introduced. They also applied the coatings to commercially available spinal implants and monitored strain to the implants in sheep spines under normal load for device failure diagnosis. The coatings performed both functions well.

The prototype electronics required wires, but the researchers’ next plan to develop wireless power and data communications interfaces for their coatings, a crucial step for clinical application, Cao said. They also are working to develop large-scale production of the nanopillar-textured bacteria-killing foil.

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“These types of antibacterial coatings have a lot of potential applications, and since ours uses a mechanical mechanism, it has potential for places where chemicals or heavy metal ions – as are used in commercial antimicrobial coatings now – would be detrimental,” Cao said.

Reference: “A smart coating with integrated physical antimicrobial and strain-mapping functionalities for orthopedic implants” by Yi Zhang, Jinsong Cui, Kuan-Yu Chen, Shanny Hsuan Kuo, Jaishree Sharma, Rimsha Bhatta, Zheng Liu, Austin Ellis-Mohr, Fufei An, Jiahui Li, Qian Chen, Kari D. Foss, Hua Wang, Yumeng Li, Annette M. McCoy, Gee W. Lau and Qing Cao, 5 May 2023, Science Advances.
DOI: 10.1126/sciadv.adg7397

The National Science Foundation and the U.S. Congressionally Directed Medical Research Programs supported this work.

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