Monthly Archives: July 2023

Clustering of the causes of death in Northeast Iran: a mixed growth modeling

One of the sustainable development goals is good health and well-being [23]. A decrease in mortality is considered a sign of a healthy community. The study of death and its causes is an essential topic worldwide, and this research can help in seeking a more sustainable future for the population’s health. As a consequence, it […]

2023-07-19 | NDAQ:KPTI | Press Release

– Data Provide Further Support for Company’s Ongoing Phase 3 Study Evaluating Selinexor as Maintenance Therapy Following Systemic Therapy in Patients with Advanced or Recurrent TP53 Wild-Type Endometrial Cancer – NEWTON, Mass. , July 19, 2023 /PRNewswire/ — Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that an […]

Circulating microRNAs in young individuals with long-duration type 1 diabetes in comparison with healthy controls

Abstract MicroRNAs (miRNAs) are short non-coding RNAs that are involved in post-transcriptional control of gene expression and might be used as biomarkers for diabetes-related complications. The aim of this case–control study was to explore potential differences in circulating miRNAs in young individuals with long-duration type 1 diabetes (T1D) compared to healthy controls, and how identified […]

Gadopiclenol comparable to gadobutrol at half-dose for body MRI

The findings suggest that gadopiclenol shows promise as an alternative to other gadolinium-based contrast agents (GBCAs), which have prompted some concern about the potential for kidney injury, according to a group led by Christiane Kuhl, MD, from Aachen University Hospital in Germany. “Gadopiclenol offers a substantially higher relaxivity than current state-of-the-art GBCAs,” Kuhl and colleagues […]

Had COVID but no symptoms? You might have this genetic mutation

Asymptomatic infections with SARS-CoV-2 are common, thanks in part, perhaps, to a newly identified genetic mutation.Credit: Sean Gallup/Getty At least 20% of people who become infected with the SARS-CoV-2 coronavirus never feel sick. Now scientists have identified a genetic mutation that is linked to a higher likelihood of avoiding symptoms during infection1. This mutation might […]

A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection

Abstract Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic1,2,3,4. Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic infection provides a unique opportunity to consider early immunological features that promote rapid viral clearance. Here, postulating that variation in the human leukocyte antigen (HLA) loci may […]

The sum of the parts is greater than the whole: current research models for congenital heart disease

Several experimental systems have been used over the past five decades to address important questions in cardiac development and congenital heart disease. Here we discuss the strengths and limitations of available models, and how the use of different models synergistically is needed for a deeper understanding of these complex diseases. Congenital heart defects are the […]