Monthly Archives: July 2023

Spokane-area experiences a 25% decrease in blood supply, experts say, it’s an “emergency”

SPOKANE COUNTY, Wash.– Local health professionals are calling on Spokane residents to donate blood. The area is experiencing a 25% decrease in blood supply since May. According to Vitalant, a blood donation organization, there is less than a 3-day supply of most blood types. The Spokane area has been experiencing a blood shortage since the […]

‘Exhausted supplies’: Aussie mum-of-two desperately seeking ultra-rare blood donor for urgent open-heart surgery

A desperate appeal is underway to find a match for an Australian mother-of-two’s extremely rare blood type as she awaits urgent and life-saving open-heart surgery. Adelaide mum Amira, 37, has a blood type so rare just one in 10,000 people might be a match, a figure officials say has prompted them to look overseas, after […]

Nutley hosting blood drive in August

The Nutley Department of Public Affairs and Health has partnered with Vitalant Blood Services of New Jersey to conduct community blood drive Thursday, Aug. 17, from 1 to 6 p.m., at 149 Chestnut St. (the Public Affairs office). Although walk-ins are accepted, appointments are suggested and will be taken before walk-ins. All safety precautions will […]

Plasma proteome of growing tumors

Abstract Early detection of cancer is vital for the best chance of successful treatment, but half of all cancers are diagnosed at an advanced stage. A simple and reliable blood screening test applied routinely would therefore address a major unmet medical need. To gain insight into the value of protein biomarkers in early detection and […]

Neo-Nazi Ex-Marine Buys Up Land in Rural Maine for ‘Blood Tribe’

“Let’s just be frank, Maine’s a white state, has always been a super-white state. Let’s keep it the way it is,” Pohlhaus said in a May 11 interview with a journalist that Pohlhaus recorded and posted to Telegram. A photograph from April 30, 2023, shows Pohlhaus and an unidentified individual in an undisclosed location holding […]

Lab-on-a-chip enhances stored blood cell assessment

Ziya Isiksacan, PhD, a research fellow in the Center for Engineering in Medicine and Surgery (CEMS) is the lead author, and Osman Berk Usta, PhD, an investigator in the CEMS at Massachusetts General Hospital and an associate professor of Surgery at Harvard Medical School, is the senior author of a new study published in PNAS, Assessment of Stored Red Blood Cells […]

Cellular state landscape and herpes simplex virus type 1 infection progression are connected

Abstract Prediction, prevention and treatment of virus infections require understanding of cell-to-cell variability that leads to heterogenous disease outcomes, but the source of this heterogeneity has yet to be clarified. To study the multimodal response of single human cells to herpes simplex virus type 1 (HSV-1) infection, we mapped high-dimensional viral and cellular state spaces […]

Metabolic systems approaches update molecular insights of clinical phenotypes and cardiovascular risk in patients with homozygous familial hypercholesterolemia

Demographic and clinical characteristics of all participants A total of 660 individuals participated in the discovery cross-sectional study (Fig. 1a), including 184 genetically confirmed HoFH patients (male, 50.1%), 376 HeFH patients (male, 49.2%), and 100 non-FH individuals (male, 53.0%). The clinical characteristics of the study individuals are presented in Table 1. Patients with HoFH had higher […]

microRNA sequencing for biomarker detection in the diagnosis, classification and prognosis of Diffuse Large B Cell Lymphoma

Abstract Despite being considered a single disease, Diffuse Large B Cell Lymphoma (DLBCL) presents with variable backgrounds, which results in heterogeneous outcomes among patients, with 40% of them still having primary refractory disease or relapse. Thus, novel biomarkers are needed. In addition, multiple factors regarding its pathogenesis remain unclear. In this context, recent investigations point […]

Phenotypes, cardiovascular disease . . . and other stories

Genome-wide association studies of cardiovascular disease According to the NHGRI-EBI catalogue of human genome-wide association studies (https://www.ebi.ac.uk/gwas), 1700 studies have been performed on phenotypes related to common cardiovascular diseases, such as coronary artery disease, atrial fibrillation, stroke, and hypertension. Hundreds of genomic loci associated with these phenotypes have been identified. Although polygenic scores that summarise […]