Space Travel Depletes Red Blood Cells And Bone, But Bone Marrow Fat May Come To The Rescue

A study of 14 astronauts suggests that while space travel depletes red blood cells and bone, the body can eventually replenish them back on Earth with the help of fat stored in the bone marrow. The study, published in Nature Communications, has important implications for health in space and on Earth.

“We found that astronauts had significantly less fat in their bone marrow about a month after returning to Earth,” said senior study author Dr. Guy Trudel, a rehabilitation physician and researcher at The Ottawa Hospital and professor at the University of Ottawa. “We think the body is using this fat to help replace red blood cells and rebuild bone that has been lost during space travel.”

This study builds on Dr. Trudel’s previous research which showed that during space travel, astronauts’ bodies destroyed 54 percent more red blood cells than they normally would on Earth, resulting in what is known as “space anemia.” This research is part of MARROW, a made-in-Ottawa experiment looking at bone marrow health and blood production in space, with funding from the Canadian Space Agency.

“Thankfully, anemia isn’t a problem in space when your body is weightless, but when landing on Earth and potentially on other planets or moons with gravity, anemia would affect energy, endurance, and strength and could threaten mission objectives,” said Dr. Trudel. “If we can find out exactly what’s controlling this anemia, we might be able to improve prevention and treatment.”

The new study involved MRI scans of the astronauts’ bone marrow at multiple time points before and after a six-month mission at the International Space Station. The researchers found a 4.2 percent decrease in bone marrow fat about a month after returning to Earth. This gradually returned to normal levels and was closely associated with increased production of red blood cells and restoration of bone.

“Since red blood cells are made in the bone marrow and bone cells surround the bone marrow, it makes sense that the body would use up the local bone marrow fat as a source of energy to fuel red blood cell and bone production,” said Dr. Trudel. “We look forward to investigating this further in various clinical conditions on Earth.”

The research also suggests that younger astronauts may have an increased ability to harness the energy from bone marrow fat, and that female astronauts’ bone marrow fat increased more than expected after a year.

a A male astronaut. b A female astronaut. In this male astronaut, the heat map displays decreased bone marrow adiposity (BMA) in lumbar vertebrae 41 days postflight (colder colour at L4; white asterisk) and recovery 1-year postflight compared to preflight. In this female astronaut, the heat map displays decreased BMA in lumbar vertebrae 41 days postflight and increased BMA 1-year postflight (warmer colour at L4; white pound symbol) compared to preflight. White arrows point to the L4 vertebra. c, d High resolution 1H-MRS spectra from the L4 vertebral body in (c) a male astronaut; and (d) a female astronaut preflight and 41 days, 184, and 363 days postflight. Shown are eight spectra with the corresponding LCModel fit as a red line over each spectrum. Above each spectrum, the residuum of the LCModel fit is displayed, showing low noise residua and excellent fitting results of the resonances. The lipid methylene group at 1.3 ppm is, relative to the water resonance, decreasing at 41 days postflight (black arrows) and gradually increasing at 184 days and 1-year postflight for both vertebrae shown. – -Nature Communications

As a rehabilitation physician, most of Dr. Trudel’s patients are anemic and have lost muscle and bone mass after being ill for a long time with limited mobility. Anemia hinders their ability to exercise and recover muscle and bone mass. “I’m hopeful that this research will help people recover from immobility on Earth as well as in space,” said Dr. Trudel. “Our research could also shed light on diseases such as osteoporosis, metabolic syndrome, aging and cancer, which are associated with increases in bone marrow fat.”

Dr. Trudel recently received the 2023 Compelling Results Award for Human Health in Space for his research on space anemia, jointly presented by NASA, the Center for the Advancement of Science in Space and the American Astronautical Society.

Full reference: “Bone marrow adiposity modulation after long duration spaceflight in astronauts”. Tammy Liu, Gerd Melkus, Tim Ramsay, Adnan Sheikh, Odette Laneuville & Guy Trudel. Nature Communications volume 14, Article number: 4799 (2023). Published 09 August 2023.

Funding and support: The MARROW study is funded by the Canadian Space Agency. Dr. Scott Smith and the NASA Biochemical Profile Protocol provided support. The Ottawa Hospital Research Institute and the University of Ottawa Faculty of Medicine have also supported this research through the Ottawa Methods Centre and Blueprint Translational Research Group’s Excelerator program.

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Bone marrow adiposity modulation after long duration spaceflight in astronauts, Nature COmmunications (open access)