Monthly Archives: August 2023

Congenital disorders

Reduced ADP off-rate by the yeast CCT2 double mutation T394P/R510H which causes Leber congenital amaurosis in humans

Posted on by yun
29
Aug

Abstract The CCT/TRiC chaperonin is found in the cytosol of all eukaryotic cells and assists protein folding in an ATP-dependent manner. The heterozygous double mutation T400P and R516H in subunit CCT2 is known to cause Leber congenital amaurosis (LCA), a hereditary congenital retinopathy. This double mutation also renders the function of subunit CCT2, when it […]

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Infection

Neonatal and maternal outcomes following SARS-CoV-2 infection and COVID-19 vaccination: a population-based matched cohort study

Posted on by yun
29
Aug

Abstract Understanding the impact of SARS-CoV-2 infection and COVID-19 vaccination in pregnancy on neonatal and maternal outcomes informs clinical decision-making. Here we report a national, population-based, matched cohort study to investigate associations between SARS-CoV-2 infection and, separately, COVID-19 vaccination just before or during pregnancy and the risk of adverse neonatal and maternal outcomes among women […]

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Cardiovascular

Long-term cardiovascular outcomes of biodegradable polymer drug eluting stents in patients with diabetes versus non-diabetes mellitus: a meta-analysis

Posted on by yun
29
Aug

Search databases Cochrane central, MEDLINE (Subset PubMed), EMBASE, Web of Science, http://www.ClinicalTrials.gov and Google scholar were searched for relevant publications involving BP-DES in patients with DM versus non-DM. Search strategies The above mentioned databases were searched for relevant publications using the following search terms: ‘biodegradable polymer drug eluting stents and diabetes mellitus’, ‘biodegradable polymer DES […]

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Cardiovascular

With a heavy heart: Cardiovascular disease is costing the EU 11% of its overall health budget

Posted on by yun
29
Aug

29 Aug 2023 — The European Society of Cardiology (ESC), in collaboration with the University of Oxford, has presented staggering figures about the cost of cardiovascular diseases on European health care expenses, estimated at €282 billion (US$305 billion) from data collected and processed in 2021. The cost of general health care and long-term care alone […]

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Cardiovascular

Early elevation of high-sensitivity C-reactive protein as a predictor for cardiovascular disease incidence and all-cause mortality: a landmark analysis

Posted on by yun
29
Aug

Abstract We investigated the association between early elevation of high-sensitivity C-reactive protein (hsCRP) and cardiovascular disease (CVD) incidence, all-cause mortality, and CVD mortality. We analyzed 6567 participants from the Korean Genome and Epidemiology Study_Ansan_Ansung cohort between 2005 and 2018. The Kaplan–Meier curves and modified Cox regression by Fine and Gray were used to estimate hazard […]

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Congenital disorders

Fertility-enhancing hysteroscopic surgery; multi-center retrospective cohort study of reproductive outcome

Posted on by yun
29
Aug

Grimbizis GF. Uterine septum. In: Metwally M, Li TC, editors. Reproductive surgery in assisted conception. London: Springer; 2015. https://doi.org/10.1007/978-1-4471-4953-8_20. Chapter  Google Scholar  Saravelos SH, Cocksedge KA, Li TC. Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure: a critical appraisal. Hum Reprod Update 2008 Sep-Oct;14(5):415–29. doi: https://doi.org/10.1093/humupd/dmn018. Epub 2008 Jun 6. PMID: […]

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Congenital disorders

Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease

Posted on by yun
29
Aug

Abstract Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; thus, the conformation of the microbiome may determine if tolerant immune […]

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Infection

COVID-19 Evolves Three Times Faster in Deer Than Humans: Study

Posted on by yun
29
Aug

Representative Image (IANS) COVID-19 viral variants can evolve about three times faster in deer than in humans, according to a study that documented at least 30 COVID-19 infections in white-tailed deer in the US that were introduced by humans. The study, published in Nature Communications, showed that white-tailed deer across Ohio, US, have increasingly been […]

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Infection

Living Worm Discovered in Australian Patient’s Brain

Posted on by yun
29
Aug

SYDNEY —  An 8-centimeter worm has been found alive in the brain of a woman in Australia, and researchers say it is the first time the parasite has ever been discovered in humans. The worm was extracted from the patient’s brain during surgery in the Australian capital, Canberra, in June 2022. The extraordinary case has […]

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Congenital disorders

Mumbai Confirms Zika Case! Learn All About the Virus Lethal For Pregnancy and Infants

Posted on by yun
29
Aug

Representational image (IANS) Mumbai has been thrown into a tizzy after a 79-year-old Chembur resident was reported to have the city’s first case of Zika Virus. While the patient successfully recovered and no other positive patients have been identified so far, the disease could pose a serious threat to pregnant people and their babies in […]

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