Influence of lymphadenectomy on survival and recurrence in patients with early-stage epithelial ovarian cancer: a meta-analysis

  • Viale PH. The American Cancer Society’s facts & figures: 2020 Edition. J Adv Practitioner Oncol. 2020;11(2):135–6.

    Google Scholar 

  • Wang Z, Guo E, Yang B, Xiao R, Lu F, You L, Chen G. Trends and age-period-cohort effects on mortality of the three major gynecologic cancers in China from 1990 to 2019: cervical, ovarian and uterine cancer. Gynecol Oncol. 2021;163(2):358–63.

    PubMed 

    Google Scholar 

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71(3):209–49.

    Google Scholar 

  • Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A, Siegel RL. Ovarian cancer statistics, 2018. Cancer J Clin. 2018;68(4):284–96.

    Google Scholar 

  • Deng T, Huang Q, Wan T, Luo X, Feng Y, Huang H, Liu J. The impact of lymph node dissection on survival in patients with clinical early-stage ovarian cancer. J Gynecol Oncol. 2021;32(3):e40.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Heitz F, Harter P, Ataseven B, Heikaus S, Schneider S, Prader S, Bommert M, Fisseler-Eckhoff A, Traut A, du Bois A. Stage- and histologic subtype-dependent frequency of Lymph Node Metastases in patients with epithelial ovarian Cancer undergoing systematic pelvic and paraaortic lymphadenectomy. Ann Surg Oncol. 2018;25(7):2053–9.

    PubMed 

    Google Scholar 

  • Li T, Liu Y, Xie S, Wang H. Systematic pelvic and para-aortic lymphadenectomy during fertility-sparing surgery in patients with early-stage epithelial ovarian Cancer: a retrospective study. Front Oncol. 2022;12:913103.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Yoshihara M, Tamauchi S, Iyoshi S, Kitami K, Uno K, Tano S, Matsui S, Kajiyama H. Does complete-staging lymphadenectomy improve survival outcomes in stage I endometrioid epithelial ovarian carcinoma? A multi-institutional retrospective study with propensity score-weighted analysis. Jpn J Clin Oncol. 2021;51(3):387–92.

    PubMed 

    Google Scholar 

  • Bizzarri N, du Bois A, Fruscio R, De Felice F, De Iaco P, Casarin J, Vizza E, Chiantera V, Corrado G, Cianci S, et al. Is there any therapeutic role of pelvic and para-aortic lymphadenectomy in apparent early stage epithelial ovarian cancer? Gynecol Oncol. 2021;160(1):56–63.

    PubMed 

    Google Scholar 

  • Chiyoda T, Sakurai M, Satoh T, Nagase S, Mikami M, Katabuchi H, Aoki D. Lymphadenectomy for primary ovarian cancer: a systematic review and meta-analysis. J Gynecol Oncol. 2020;31(5):e67.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Gao J, Yang X, Zhang Y. Systematic lymphadenectomy in the treatment of epithelial ovarian cancer: a meta-analysis of multiple epidemiology studies. Jpn J Clin Oncol. 2015;45(1):49–60.

    PubMed 

    Google Scholar 

  • Lin Q, Liu W, Xu S, Li J, Tong J. The value of systematic lymphadenectomy during debulking surgery in the treatment of ovarian cancer: a meta-analysis of randomized controlled trials. J Ovarian Res. 2020;13(1):56.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhou J, Shan G, Chen Y. The effect of lymphadenectomy on survival and recurrence in patients with ovarian cancer: a systematic review and meta-analysis. Jpn J Clin Oncol. 2016;46(8):718–26.

    PubMed 

    Google Scholar 

  • Kim HS, Ju W, Jee BC, Kim YB, Park NH, Song YS, Kim SC, Kang SB, Kim JW. Systematic lymphadenectomy for survival in epithelial ovarian cancer: a meta-analysis. Int J Gynecol cancer: Official J Int Gynecol Cancer Soc. 2010;20(4):520–8.

    Google Scholar 

  • Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Lo CK-L, Mertz D, Loeb M. Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments. BMC Med Res Methodol. 2014;14:45.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Tarsilla M. Cochrane Handbook for systematic reviews of interventions. J Multidisciplinary Evaluation. 2008;6:142–8.

    Google Scholar 

  • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Matsuo K, Machida H, Mariani A, Mandelbaum RS, Glaser GE, Gostout BS, Roman LD, Wright JD. Adequate pelvic lymphadenectomy and survival of women with early-stage epithelial ovarian cancer. J Gynecol Oncol. 2018;29(5):e69.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Abe A, Furumoto H, Irahara M, Ino H, Kamada M, Naka O, Sasaki M, Kagawa T, Okitsu O, Kushiki N. The impact of systematic para-aortic and pelvic lymphadenectomy on survival in patients with optimally debulked ovarian cancer. J Obstet Gynaecol Res. 2010;36(5):1023–30.

    PubMed 

    Google Scholar 

  • Chen Q, Wang S, Lang JH. The impact of lymph node dissection on apparent stage I epithelial ovarian carcinoma: a population-based study. Int J Gynaecol Obstet. 2021;154(3):550–7.

    PubMed 

    Google Scholar 

  • Ho CM, Chien TY, Shih BY, Huang SH. Evaluation of complete surgical staging with pelvic and para-aortic lymphadenectomy and paclitaxel plus carboplatin chemotherapy for improvement of survival in stage I ovarian clear cell carcinoma. Gynecol Oncol. 2003;88(3):394–9.

    CAS 
    PubMed 

    Google Scholar 

  • Maggioni A, Benedetti Panici P, Dell’Anna T, Landoni F, Lissoni A, Pellegrino A, Rossi RS, Chiari S, Campagnutta E, Greggi S, et al. Randomised study of systematic lymphadenectomy in patients with epithelial ovarian cancer macroscopically confined to the pelvis. Br J Cancer. 2006;95(6):699–704.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nasioudis D, Haggerty AF, Giuntoli RL 2nd, Burger RA, Morgan MA, Ko EM, Latif NA. Adjuvant chemotherapy is not associated with a survival benefit for patients with early stage mucinous ovarian carcinoma. Gynecol Oncol. 2019;154(2):302–7.

    PubMed 

    Google Scholar 

  • Oshita T, Itamochi H, Nishimura R, Numa F, Takehara K, Hiura M, Tanimoto H, Noma J, Hayase R, Murakami A, et al. Clinical impact of systematic pelvic and para-aortic lymphadenectomy for pT1 and pT2 ovarian cancer: a retrospective survey by the Sankai Gynecology Study Group. Int J Clin Oncol. 2013;18(6):1107–13.

    CAS 
    PubMed 

    Google Scholar 

  • Svolgaard O, Lidegaard O, Nielsen ML, Nedergaard L, Mosgaard BJ, Lidang M, Mogensen O, Kock K, Blaakaer J, Staehr E, et al. Lymphadenectomy in surgical stage I epithelial ovarian cancer. Acta Obstet Gynecol Scand. 2014;93(3):256–60.

    PubMed 

    Google Scholar 

  • Yamazaki H, Todo Y, Shimada C, Takeshita S, Minobe S, Okamoto K, Yamashiro K, Kato H. Therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma. J Gynecol Oncol. 2018;29(2):e19.

    PubMed 

    Google Scholar 

  • Yoshihara M, Kajiyama H, Tamauchi S, Iyoshi S, Yokoi A, Suzuki S, Kawai M, Nagasaka T, Takahashi K, Matsui S, et al. Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis. Jpn J Clin Oncol. 2020;50(2):145–51.

    PubMed 

    Google Scholar 

  • Zhao Y, Wang S, Qu YM, Ji YT, Shen K, Lang JH. Prognostic analysis for chinese patients with stage I ovarian endometrioid carcinoma. J Ovarian Res. 2017;10(1):63.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kleppe M, Wang T, Van Gorp T, Slangen BFM, Kruse AJ, Kruitwagen RFPM. Lymph node metastasis in stages I and II ovarian cancer: a review. Gynecol Oncol. 2011;123(3):610–4.

    CAS 
    PubMed 

    Google Scholar 

  • Kossaï M, Leary A, Scoazec J-Y, Genestie C. Ovarian Cancer: a heterogeneous disease. Pathobiology. 2018;85(1–2):41–9.

    PubMed 

    Google Scholar 

  • Imterat M, Harter P. Early-stage epithelial ovarian cancer: is systematic lymph node staging mandatory? J Gynecologic Oncol. 2021;32(4):e61.

    Google Scholar 

  • Kleppe M, van der Aa MA, Van Gorp T, Slangen BF, Kruitwagen RF. The impact of lymph node dissection and adjuvant chemotherapy on survival: a nationwide cohort study of patients with clinical early-stage ovarian cancer. Eur J Cancer. 2016;66:83–90.

    PubMed 

    Google Scholar 

  • Powless CA, Aletti GD, Bakkum-Gamez JN, Cliby WA. Risk factors for lymph node metastasis in apparent early-stage epithelial ovarian cancer: implications for surgical staging. Gynecol Oncol. 2011;122(3):536–40.

    PubMed 

    Google Scholar 

  • Benedetti Panici P, Giannini A, Fischetti M, Lecce F, Di Donato V. Lymphadenectomy in Ovarian Cancer: is it still justified? Curr Oncol Rep. 2020;22(3):22.

    PubMed 

    Google Scholar 

  • Harter P, Sehouli J, Lorusso D, Reuss A, Vergote I, Marth C, Kim J-W, Raspagliesi F, Lampe B, Aletti G, et al. A Randomized Trial of Lymphadenectomy in patients with Advanced Ovarian Neoplasms. N Engl J Med. 2019;380(9):822–32.

    PubMed 

    Google Scholar 

  • Lheureux S, Gourley C, Vergote I, Oza AM. Epithelial ovarian cancer. Lancet. 2019;393(10177):1240–53.

    PubMed 

    Google Scholar 

  • Ramalingam P. Morphologic, immunophenotypic, and molecular features of epithelial ovarian Cancer. Oncol (Williston Park). 2016;30(2):166–76.

    Google Scholar 

  • Falcetta FS, Medeiros LR, Edelweiss MI, Pohlmann PR, Stein AT, Rosa DD. Adjuvant platinum-based chemotherapy for early stage cervical cancer. Cochrane Database Syst Rev. 2016;11:CD005342.

    PubMed 

    Google Scholar 

  • Oseledchyk A, Leitao MM, Konner J, O’Cearbhaill RE, Zamarin D, Sonoda Y, Gardner GJ, Long Roche K, Aghajanian CA, Grisham RN, et al. Adjuvant chemotherapy in patients with stage I endometrioid or clear cell ovarian cancer in the platinum era: a Surveillance, Epidemiology, and end results Cohort Study, 2000–2013. Ann Oncol. 2017;28(12):2985–93.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Di Donato V, Giannini A, D’Oria O, Schiavi MC, Di Pinto A, Fischetti M, Lecce F, Perniola G, Battaglia F, Berloco P, et al. Hepatobiliary disease resection in patients with Advanced Epithelial Ovarian Cancer: Prognostic Role and Optimal Cytoreduction. Ann Surg Oncol. 2021;28(1):222–30.

    PubMed 

    Google Scholar 

  • Matsuo K, Klar M, Nusbaum DJ, Hasanov MF, Vallejo A, Ciesielski KM, Muderspach LI, Roman LD, Wright JD. Utilization and outcomes of Sentinel Lymph Node Biopsy for Early Endometrial Cancer. Obstet Gynecol. 2022;139(5):809–20.

    PubMed 

    Google Scholar 

  • Niikura H, Tsuji K, Tokunaga H, Shimada M, Ishikawa M, Yaegashi N. Sentinel node navigation surgery in cervical and endometrial cancer: a review. Jpn J Clin Oncol. 2019;49(6):495–500.

    PubMed 

    Google Scholar 

  • Lago V, Bello P, Montero B, Matute L, Padilla-Iserte P, Lopez S, Marina T, Agudelo M, Domingo S. Sentinel lymph node technique in early-stage ovarian cancer (SENTOV): a phase II clinical trial. Int J Gynecol cancer: Official J Int Gynecol Cancer Soc. 2020;30(9):1390–6.

    Google Scholar 

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