FXI Inhibitor Cuts Bleeds in Afib; COAPT Extends to Real World; AI Stroke Triage

People who were prone to needing dentures tended to also be at higher risk of cardiometabolic disease. (European Journal of Preventive Cardiology)

Early real-world experience at a Dutch lipid clinic suggests smaller LDL cholesterol reductions with inclisiran (Leqvio) than what was seen in clinical trials. (Journal of Clinical Lipidology)

PCSK9 inhibitor therapy led some people to discontinue their statin use. (Journal of the American Heart Association)

Healthy meals do not offset the cardiometabolic ills of unhealthy snacking, an observational study finds. (European Journal of Nutrition)

Anthos Therapeutics announced that abelacimab, a factor XI inhibitor, reduced major bleeding compared with rivaroxaban (Xarelto) in the AZALEA-TIMI 71 trial of people with atrial fibrillation (Afib).

Weight gain was tied to a greater risk of incident Afib, whereas weight loss did not change the risk compared with stable weight over 5 years. (European Journal of Preventive Cardiology)

In people with hypertrophic cardiomyopathy, low triiodothyronine (T3) syndrome predicted sudden cardiac death and worsening heart failure. (Clinical Cardiology)

Roughly one in three Danish children with congenital heart disease (CHD) developed a mental health condition by their 18th birthday. (Circulation)

Postpartum CHD patients may have late maternal cardiovascular events predicted by two risk scales. (Open Heart)

The U.S. Preventive Services Task Force finalized its B-level recommendation for screening for hypertensive disorders throughout pregnancy.

Another study shows aortic aneurysm and aortic dissection is not associated with fluoroquinolones. (European Heart Journal)

Perceived hard work with little reward was associated with coronary heart disease. (Circulation: Cardiovascular Quality and Outcomes)

The safety and effectiveness of MitraClip therapy for secondary mitral regurgitation was affirmed by the COAPT post-approval study. (Journal of the American College of Cardiology)

For acute stroke triage, automated large vessel occlusion detection software improved in-hospital workflows and reduced delays to thrombectomy treatment. (JAMA Neurology)

More neighborhood recreation centers correlated with better poststroke outcomes among resident stroke survivors in one Texas county. (Stroke)

Medicare plans to pay hospital-owned outpatient clinics more than physician offices for intensive cardiac rehabilitation. (STAT)

In Denmark, surveyed cardiac arrest survivors reported consistently good quality of life up to 20 years later. (JAMA Cardiology)

European regulators are losing patience waiting for cardiovascular safety data for weight-loss drug naltrexone/bupropion (Contrave; Mysimba in Europe) and will now conduct their own review.

Denver cardiologist Stephen Matthews, MD, is ordered to stand trial as he faces dozens of felony charges related to sexual assault. (CBS News)

Scientists discovered how nitric oxide, with its very short half-life, moves through the bloodstream to reach blood vessel walls. (Nature Chemical Biology)

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