Cancer and neoplasms
Clinical phenotypes, molecular analysis, and outcomes of patients with Rosai-Dorfman disease
Sep
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References
-
Abla O, Jacobsen E, Picarsic J, Krenova Z, Jaffe R, Emile JF, et al. Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. Blood. 2018;131:2877–90.
Google Scholar
-
Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127:2672–81.
Google Scholar
-
Diamond EL, Durham BH, Haroche J, Yao Z, Ma J, Parikh SA, et al. Diverse and targetable kinase alterations drive histiocytic neoplasms. Cancer Discov. 2016;6:154–65.
Google Scholar
-
Goyal G, Ravindran A, Young JR, Shah MV, Bennani NN, Patnaik MM, et al. Clinicopathological features, treatment approaches, and outcomes in Rosai-Dorfman Disease. Haematologica. 2020;105:348–57.
Google Scholar
-
Chen J, Zhao AL, Duan MH, Cai H, Gao XM, Liu T, et al. Diverse kinase alterations and myeloid-associated mutations in adult histiocytosis. Leukemia. 2022;36:573–6.
Google Scholar
-
Goyal G, Tazi A, Go RS, Rech KL, Picarsic JL, Vassallo R, et al. International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults. Blood. 2022;139:2601–21.
Google Scholar
-
Saboo SS, Jagannathan JP, Krajewski KM, O’Regan K, Hornick JL, Fisher DC, et al. Symptomatic extranodal Rosai-Dorfman disease treated with steroids, radiation, and surgery. J Clin Oncol. 2011;29:e772–e775.
Google Scholar
-
Chen E, Pavlidakey P, Sami N. Rosai-Dorfman disease successfully treated with thalidomide. Jaad Case Rep. 2016;2:369–72.
Google Scholar
-
Rubinstein M, Assal A, Scherba M, Elman J, White R, Verma A, et al. Lenalidomide in the treatment of Rosai Dorfman disease–a first in use report. Am J Hematol. 2016;91:E1.
Google Scholar
-
Abeykoon JP, Rech KL, Young JR, Ravindran A, Ruan GJ, Dasari S, et al. Outcomes after treatment with cobimetinib in patients with Rosai-Dorfman disease based on KRAS and MEK alteration status. JAMA Oncol. 2022;8:1816–20.
Google Scholar
Funding
This study was funded by the National Key R&D Program of China, Ministry of Science and Technology of the People’s Republic of China (2022YFC2304605), Beijing Natural Science Haidian frontier Foundation (Grant No. L222081 to XXC) and the National High Level Hospital Clinical Research Funding (2022-PUMCH-B-046).
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Contributions
LC, BQ, CYS, and XXC contributed to study conception and design; LC and HC contributed to data collection and analysis, HL contributed to patient follow-up; JL, MHD, DBZ, and GG retrospectively reviewed patient records; LC, BQ, CYS, and XXC wrote the paper; and all authors revised the paper and approved the submitted version.
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GG served on advisory board for Opna Bio LLC.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
InformeInformed consent was obtained from all patients included in thed consent was obtained from all patients included in the study.
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Chang, L., Qiao, B., Cai, H. et al. Clinical phenotypes, molecular analysis, and outcomes of patients with Rosai-Dorfman disease.
Leukemia (2023). https://doi.org/10.1038/s41375-023-02032-6
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Received: 21 April 2023
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Revised: 16 August 2023
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Accepted: 08 September 2023
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Published: 20 September 2023
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DOI: https://doi.org/10.1038/s41375-023-02032-6
