Sympathetic nerves suppress T-cell responses in infection and in cancer

  • RESEARCH BRIEFINGS
  • 20 September 2023

T cells that are chronically stimulated in viral infection or cancer enter a dysfunctional state known as T-cell exhaustion. Sympathetic nerves in tissues and tumours drive T-cell exhaustion through the action of the neurotransmitter noradrenaline on the β1-adrenergic receptors of T cells, with implications for cancer treatment.

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