Ultrasensitive Blood Test Detects ‘Pan-Cancer’ Biomarker

Authorship: Co-first authors are Martin S. Taylor and Connie Wu. Co-authors include Peter C. Fridy, Stephanie J. Zhang, Yasmeen Senussi, Justina C. Wolters, Tatiana Cajuso, Wen-Chih Cheng, John D. Heaps, Bryant D. Miller, Kei Mori, Limor Cohen, Hua Jiang, Kelly R. Molloy, Brian T. Chait, Michael G. Goggins, Irun Bhan, Joseph W. Franses, Xiaoyu Yang, Mary-Ellen Taplin, Xinan Wang, David C. Christiani, Bruce E. Johnson, Matthew Meyerson, Ravindra Uppaluri, Ann Marie Egloff, Elyssa N. Denault, Laura M. Spring, Tian-Li Wang, Ie-Ming Shih, Jennifer E. Fairman, Euihye Jung, Kshitij S. Arora, Osman H. Yilmaz, Sonia Cohen, Tatyana Sharova, Gary Chi, Bryanna L. Norden, Yuhui Song, Linda T. Nieman, Leontios Pappas, Aparna R. Parikh, Matthew R. Strickland, Ryan B. Corcoran, Tomas Mustelin, George Eng, Omer H. Yilmaz, Ursula A. Matulonis, Steven J. Skates, Bo R. Rueda, Ronny Drapkin, Samuel J. Klempner, Vikram Deshpande, David T. Ting, Michael P. Rout, and John LaCava. Co-senior authors are David R. Walt and Kathleen H. Burns.

Disclosures: MST and JL have equity in ROME therapeutics. LMS declares the following relationships: Consultant/advisory board: Novartis, Puma, G1 therapeutics, Daiichi Pharma, Astra Zeneca,Institutional research support: Phillips, Merck, Genentech, Gilead, Eli Lilly. SJK declares Consulting/advisory: Eli Lilly, Merck, BMS, Novartis, Astellas, AstraZeneca, Daiichi- Sankyo, Novartis, Sanofi-Aventis, Natera, Exact Sciences, Mersana. Stock/Equity: Turning Point Therapeutics, Nuvalent. DRW has a financial interest in Quanterix Corporation, a company that develops an ultra-sensitive digital immunoassay platform. He is an inventor of the Simoa technology, a founder of the company and also serves on its Board of Directors. KHB declares relationships with Alamar Biosciences, Genscript, Oncolinea/PrimeFour Therapeutics, ROME Therapeutics, Scaffold Therapeutics, Tessera Therapeutics, and Transposon Therapeutics. MST and KHB receive royalties from sales of ORF1p antibodies and MST, CW, PCF, KRM, BTC, MPR, JL, DRW, and KHB are inventors on a patent related to this work.

Funding: This work was supported by the National Institutes of Health (R01GM130680, K08DK129824, F32EB029777, R01CA240924, U01CA228963, P41GM109824, T32CA009216, U01CA233364, U2CCA271871, U01CA152990, R01GM126170, P50CA228991, P50CA240243, P30CA006516), Break Through Cancer, Earlier.Org, Minnesota Ovarian Cancer Alliance, Department of Defense (W81XWH-22-1-0852), Canary Foundation, Gray Foundation, The Concord (MA) Detect Ovarian Cancer Early Fund, Good Ventures (Open Philanthropy Project), Friends of Dana-Farber Cancer Institute, Dana-Farber Cancer Institute, the Dana-Farber/Harvard Cancer Center (DF/HCC), ACD-Biotechne, Robert L. Fine Cancer Research Foundation, Worldwide Cancer Research grant 19-0223, Robertson Therapeutic Development Fund, Nile Albright Research Foundation, Vincent Memorial Research Foundation, Stand Up to Cancer Gastric Cancer Interception Research Team Grant (SU2C-AACR-DT-30-20), American Association for Cancer Research, the Scientific Partner of SU2C.

Paper cited: Taylor, M. et al. “Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker” Cancer Discovery. DOI: 10.1158/2159-8290.CD-23-0313