What is Inverse Psoriasis—and What’s the Best Way to Treat It?

This rash appears in sweaty skin folds.

Psoriasis, classified as a chronic autoimmune skin disorder, is distinguished by the accelerated proliferation of skin cells, leading to the development of inflamed, elevated patches adorned with silver-white scales. While conventional psoriasis predominantly emerges on body areas like the elbows and knees, there exists a particular variant recognized as inverse psoriasis, which manifests with its unique attributes. Often termed “hidden psoriasis,” this variant starkly contrasts both in appearance and its predilection for specific anatomical locations on the body.

Inverse psoriasis stands out because it tends to emerge in skin folds or creases, presenting as smaller, pink, and sometimes itchy patches. These areas include the groin, genitals, and the undersides of the breasts. Unlike the more common plaque psoriasis, inverse psoriasis prefers regions where skin frequently rubs against skin or where moisture accumulates due to sweating. This variant affects approximately 2-6% of people with psoriasis, making it a notable subset of the condition.

Dr. Hal Weitzbuch, a dermatologist based in Calabasas, California, emphasizes the distinctiveness of inverse psoriasis due to its predilection for areas prone to chafing and moisture. The unique location and characteristics of this variant set it apart from other forms of psoriasis.

The symptoms of inverse psoriasis often manifest as a red, shiny, and smooth rash. The affected skin may feel moist to the touch, leading to irritation and itching. Interestingly, individuals with inverse psoriasis may notice worsening symptoms during warmer months or after physical activity. The combination of heat and friction can exacerbate the inflammation of this particular rash.

Moreover, those with inverse psoriasis are more susceptible to yeast or fungal infections, according to Dr. Weitzbuch. This susceptibility adds an additional layer of complexity to managing the condition.

One crucial distinction between inverse psoriasis and plaque psoriasis is the appearance of the rash. Inverse psoriasis rashes are typically shinier and less scaly compared to the raised, red patches covered with whitish dead skin cells, known as “scale,” seen in plaque psoriasis.

Given the potential confusion with other skin conditions, it is imperative to seek professional diagnosis and treatment for inverse psoriasis. Dermatologists, particularly those with expertise in psoriasis, are best equipped to accurately diagnose the condition and develop personalized treatment plans.

Treatment options for inverse psoriasis have evolved to address the unique challenges it poses. One such treatment is calcipotriene, a cream or ointment containing vitamin D3. This medication helps slow the growth of skin cells and reduces inflammation. Coal tar, a soothing gel, and Castellani’s Paint, a paint-on liquid, can also be employed to dry rashes and alleviate discomfort.

Topical corticosteroids represent another line of defense against inverse psoriasis. These creams are applied directly to the affected skin to reduce inflammation, redness, and itching. However, it’s crucial to use topical steroids under the guidance of a healthcare provider, as their prolonged use can lead to skin thinning and increased sensitivity.

Phototherapy, also known as light therapy, stands as a notable and widely recommended treatment modality within the comprehensive arsenal for addressing the challenges posed by inverse psoriasis. This therapeutic approach hinges on harnessing the potential of ultraviolet B (UVB) rays to exert a beneficial influence on the disease process by mitigating the overly rapid proliferation of skin cells, a hallmark feature of psoriasis. It is worth noting that while the use of UV light in dermatology is typically approached with caution due to its association with heightened skin cancer and melanoma risks, it paradoxically exhibits distinct anti-inflammatory properties when directed towards psoriatic skin. This paradoxical phenomenon has garnered recognition and acclaim within the field of dermatology, establishing UVB phototherapy as a valuable and compelling option for the alleviation of symptoms associated with inverse psoriasis.

Indeed, the insights shared by prominent dermatologists like Dr. Tsippora Shainhouse, based in the vibrant city of Los Angeles, lend significant credence to the potential benefits of UVB phototherapy in the management of this challenging skin condition. Dr. Shainhouse’s expertise underscores the nuanced consideration required in balancing the risks and rewards of UV therapy for psoriasis, shedding light on its utility in achieving symptom reduction while also emphasizing the importance of careful patient monitoring and diligent sun protection practices to minimize any potential adverse effects.

Over the past few years, there has been a notable emergence of cutting-edge biologic therapies designed to offer substantial relief to individuals grappling with the complexities of inverse psoriasis. These revolutionary treatments, typically delivered through intravenous infusion or subcutaneous injection, have been developed with a keen focus on targeting precise inflammatory pathways intricately linked to the pathogenesis of psoriasis. By selectively inhibiting key molecules or cell receptors responsible for orchestrating the inflammatory response and aberrant skin cell proliferation, these biologics exert a profound and specific impact on the disease process. The net result of this precision targeting is a remarkable reduction in the severity of skin rash symptoms and an improved overall quality of life for those navigating the challenges of inverse psoriasis.

In cases of inverse psoriasis that have progressed to a severe state, a dermatologist might opt for more potent treatments, such as systemic corticosteroids like prednisone. Nevertheless, it’s essential to emphasize that the efficacy of prednisone often comes with a caveat of short-term relief, as these medications can provide rapid symptom alleviation but typically yield transient results. Furthermore, the drawback of employing systemic steroids like prednisone is the increased risk of severe rebound flares once the medication is tapered or discontinued, making it imperative for patients and healthcare providers to consider the long-term management and potential alternatives for this challenging condition.

In summary, it’s important to recognize that managing inverse psoriasis, though challenging, offers various avenues for symptom relief and enhanced quality of life. Seeking guidance from a knowledgeable dermatologist who specializes in psoriasis serves as the initial crucial step in crafting a customized treatment strategy that aligns with an individual’s distinct requirements and circumstances. Timely identification and the application of appropriate management techniques are pivotal in aiding individuals in their efforts to effectively manage inverse psoriasis and navigate its particular set of challenges.