Innovation. Connection. Inspiration. The Transcatheter Cardiovascular Therapeutics (TCT) 2023 conference, the Cardiovascular Research Foundation’s (CRF) annual scientific symposium and one of the most foremost educational forums specializing in interventional cardiovascular medicine, will offer it all. TCT, which will be held October 23-26, 2023, in San Francisco at the Moscone Center, will be celebrating 35 years of leading the field.
For more than three decades, TCT has ignited innovation, education, and connection in interventional cardiology, with the purpose of improving the survival and quality of life of patients suffering from heart and vascular disease. Every year, TCT features cutting-edge research in interventional cardiovascular medicine that directly impacts patient care and how physicians treat heart disease.
In the fast-paced world of medical advancements, late-breaking trials are highly anticipated and offer clinicians the opportunity to learn about new interventions, drugs, techniques, or strategies that could potentially improve patient outcomes. The 12 studies selected for presentation at TCT examine the safety and effectiveness of minimally invasive techniques, pharmaceuticals, technologies, and devices that demonstrate potential to treat or prevent cardiovascular disease.
Late-breaking trials will be presented during the main sessions and highlighted during press conferences scheduled for Tuesday, October 24, Wednesday, October 25, and Thursday, October 26. The complete list of late-breakers is as follows.
Late-breaking Clinical Trials: Session I, in collaboration with the New England Journal of Medicine
Tuesday, October 24, 11:00 AM — 12:28 PM PDT
Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center
This content is not CME/MOC accredited
Moderators
Jane A. Leopold, Patrick T. O’Gara
Discussants
David H. Adams, Robert O. Bonow, Megan Coylewright, Victoria Delgado, Stephan Windecker, Steven J. Yakubov
11:00 am: Five-Year Clinical and Echocardiographic Outcomes From The PARTNER 3 Low-Risk Randomized Trial
Late-Breaking Trial Presenter: Martin B. Leon
11:12 am: Discussion
Lead Discussant: Stephan Windecker
11:22 am: Four-Year Outcomes From the EVOLUT Low Risk Trial
Late-Breaking Trial Presenter: Michael J. Reardon
11:34 am: Discussion
Lead Discussant: Victoria Delgado
11:44 am: Safety and Efficacy of Left Atrial Appendage Occlusion at the Time of Transcatheter Aortic Valve Replacement – WATCH TAVR Trial Results
Late-Breaking Trial Presenter: Samir R. Kapadia
11:56 am: Discussion
Lead Discussant: Megan Coylewright
12:06 pm: ALIGN-AR Trial: Initial Outcomes of the JenaValve Trilogy Transcatheter Aortic Valve Replacement in High Risk Patients With Symptomatic Severe Native Aortic Regurgitation
Late-Breaking Trial Presenter: Vinod H. Thourani
12:18 pm: Discussion
Lead Discussant: Robert O. Bonow
Late-breaking Clinical Science: Session I, in collaboration with the Journal of the American College of Cardiology
Tuesday, October 24, 2- 3:30 pm PDT
Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center
This content is not CME/MOC accredited
Moderators
David J. Cohen, David J. Moliterno
Discussants
Gorav Ailawadi, Joanna Chikwe, Linda D. Gillam, Philipp Lurz, Vivek Y. Reddy, Brian K. Whisenant
2 pm: Five-year Echocardiographic Outcomes From The PARTNER 3 Low-risk Randomized Trial
Late-Breaking Science Presenter: Rebecca T. Hahn
2:10 pm: Discussion
Lead Discussant: Linda D. Gillam
2:18 pm: Tendyne SUMMIT Pivotal Trial Roll-In and MAC Arm Outcomes
Late-Breaking Science Presenters: Jason H. Rogers, Vinod H. Thourani
2:28 pm: Discussion
Lead Discussant: Joanna Chikwe
2:36 pm: TRILUMINATE Pivotal: Outcomes of Both Randomized and Single-arm Subjects with Transcatheter Tricuspid Valve Edge-to-Edge Repair for Tricuspid Regurgitation
Late-Breaking Science Presenter: David H. Adams
2:46 pm: Discussion
Lead Discussant: Gorav Ailawadi
2:54 pm: One-Year Outcomes after Amulet or Watchman/FLX Device for Percutaneous Left Atrial Appendage Closure: a Pre-Specified Analysis of the SWISS-APERO Randomized Clinical Trial
Late-Breaking Science Presenter: Roberto Galea
3:04 pm: Discussion
Lead Discussant: Vivek Y. Reddy
3:12 pm: One-Year Outcomes with Fourth-Generation Mitral Valve Transcatheter Edge-to-Edge Repair from EXPAND G4
Late-Breaking Science Presenter: Ralph Stephan von Bardeleben
3:22 pm: Discussant
Lead Discussant: Brian K. Whisenant
Late-breaking Clinical Trials: Session II, in collaboration with The Lancet
Wednesday, October 25, 11 am — 12:28 pm PDT
Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center
This content is not CME/MOC accredited
Moderators
Roxana Mehran, Stuart Spencer
Discussants
Dominick J. Angiolillo, Roisin Colleran, David E. Kandzari, Adnan Kastrati, Jennifer Rymer, Marco Valgimigli
11:00 am: Primary Outcomes of the Esprit BTK Drug-Eluting Resorbable Scaffold for the Treatment of Infrapopliteal Lesions: The LIFE-BTK Randomized Controlled Trial
Late-Breaking Trial Presenter: Ramon L. Varcoe
11:12 am: Discussion
Lead Discussant: David E. Kandzari
11:22 am: Primary Outcomes of a Pivotal Multicenter Randomized Trial Comparing the AGENT Paclitaxel-Coated Balloon With Conventional Balloon Angioplasty for In-Stent Restenosis
Late-Breaking Trial Presenter: Robert W. Yeh
11:34 am: Discussion
Lead Discussant: Roisin Colleran
11:44 am: Less Than 1-Month Dual Antiplatelet Therapy Followed by Ticagrelor Monotherapy After Coronary Drug-Eluting Stent Implantation for Acute Coronary Syndrome: A Randomized Trial
Late-Breaking Trial Presenter: Myeong-Ki Hong
11:56 am: Discussion
Lead Discussant: Marco Valgimigli
12:06 pm: Pressure-Controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction: The Randomized PICSO-AMI-I Trial
Late-Breaking Trial Presenter: Giovanni Luigi De Maria
12:18 pm: Discussion
Lead Discussant: Adnan Kastrati
Late-breaking Clinical Science: Session II, in collaboration with Circulation
Wednesday, October 25, 2- 3:30 pm PDT
Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center
This content is not CME/MOC accredited
Moderators
Joseph A. Hill, Ajay J. Kirtane
Discussants
Fernando Alfonso, Robert A. Byrne, Akiko Maehara, Margaret B. McEntegart, Duk-Woo Park, Bruno Scheller
2:00 pm: Sirolimus-Coated Balloon Versus Paclitaxel-Coated Balloon for the Treatment of Drug-Eluting Stent In-Stent Restenosis: A Prospective, Multicenter, Randomized Trial
Late-Breaking Science Presenter: ShaoLiang Chen
2:10 pm: Discussion
Lead Discussant: Bruno Scheller
2:18 pm: The Primary Endpoint Results from the COMPARE 60/80 HBR Trial: A Randomized Controlled Multi-Center Trial Comparing Ultrathin With Thin Strut Stents in High Bleeding Risk Patients With an Abbreviated DAPT Duration
Late-Breaking Science Presenter: Pieter C. Smits
2:28 pm: Discussion
Lead Discussant: Duk-Woo Park
2:36 pm: Polymer-Free Amphilimus-Eluting Stents vs. Biodegradable-Polymer Everolimus-Eluting Stents in All-Comers Undergoing PCI: 1-Year Results of the PARTHENOPE Trial
Late-Breaking Science Presenter: Giovanni Esposito
2:46 pm: Discussion
Lead Discussant: Robert A. Byrne
2:54 pm: Long-Term Outcomes with Biodegradable Polymer Sirolimus-Eluting Stents Versus Durable Polymer Everolimus-Eluting Stents in Patients With ST-Segment Elevation Myocardial Infarction: 5-Year Follow-up of the Biostemi Randomized Trial
Late-Breaking Science Presenter: Juan F. Iglesias
3:04 pm: Discussion
Lead Discussant: Margaret B. McEntegart
3:12 pm: Long-term Clinical Outcomes After iFR vs. FFR Guided Coronary Revascularization – Insights From the SWEDEHEART National Registry
Late-Breaking Science Presenter: Matthias Götberg
3:22 pm: Discussion
Lead Discussant: Akiko Maehara
Late-breaking Clinical Trials: Session III, in collaboration with the Journal of the American Medical Association
Thursday, October 26, 11 am — 12:30 pm PDT
Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center
This content is not CME/MOC accredited
Moderators
Robert O. Bonow, Juan F. Granada
Discussants
Saif Anwaruddin, Anita W. Asgar, Suzanne J. Baron, Scott M. Chadderdon, Nimesh Desai, David Hildick-Smith, Tsuyoshi Kaneko
11:00 am: TRISCEND II: A Randomized Trial of Transcatheter Tricuspid Valve Replacement in Patients with Severe Tricuspid Regurgitation
Late-Breaking Trial Presenter: Susheel K. Kodali
11:12 am: Discussion
Lead Discussant: Nimesh Desai
11:22 am: Quality of Life After Transcatheter Tricuspid-Valve Repair vs. Medical Therapy in Patients with Severe Tricuspid Regurgitation: Results From the Randomized TRILUMINATE Pivotal Trial
Late-Breaking Trial Presenter: Suzanne V. Arnold
11:34 am: Discussion
Lead Discussant: Suzanne J. Baron
11:44 am: Trancatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis and Small Aortic Annuli: A Randomized Clinical Trial (the VIVA Trial)
Late-Breaking Trial Presenter: Josep Rodés-Cabau
11:56 am: Discussion
Lead Discussant: Saif Anwaruddin
12:06 pm: Clasp IID Updates and Complex Anatomy Registry
Late-Breaking Trial Presenters: Robert L. Smith, Firas Zahr
12:20 pm: Discussion
Lead Discussant: Anita W. Asgar
Late-Breaking Clinical Science: Session III, in Collaboration with the European Heart Journal/EuroIntervention
Thursday, October 26, 2-3:30 pm PDT
Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center
This content is not CME/MOC accredited
Moderators
Davide Capodanno, George D. Dangas
Discussants
Alexandre Abizaid, Mirvat Alasnag, Debbie Cohen, Marie-Claude Morice, Tamim M. Nazif, Amit N. Vora
2:00 pm: Individual Patient-data Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure at 6 Months in the RADIANCE Clinical Trial Program
Late-Breaking Science Presenter: Ajay J. Kirtane
2:10 pm: Discussion
Lead Discussant: Debbie Cohen
2:18 pm: Recurrent Revascularization After Treatment Of Drug-Eluting Stent Restenosis With Drug-Coated Balloon, Plain Balloon Or Drug-Eluting Stent 10-Year Results From the Randomized ISAR-DESIRE 3 Trial
Late-Breaking Science Presenter: Tobias Koch
2:28 pm: Discussion
Lead Discussant: Mirvat Alasnag
2:36 pm: Drug-Coated Balloon for Acute Coronary Syndromes: A Multicenter Randomized Non-inferiority Trial (DCB-ACS Trial)
Late-Breaking Science Presenter: Haibo Jia
2:46 pm: Discussion
Lead Discussant: Alexandre Abizaid
2:54 pm: Atrioventricular Conduction System Changes During Transcatheter Aortic Valve Replacement (TAVR): Anatomic and Electrophysiologic Predictors of Heart Block in Prospective 400 Patient EPS/TAVR Study
Late-Breaking Science Presenter: Alfred Buxton
3:04 pm: Discussion
Lead Discussant: Tamim M. Nazif
3:12 pm: Outcomes of Patients With New Left Bundle Branch Block Following Transcatheter Aortic Valve Replacement: Insights From the NCDR STS/ACC TVT Registry
Late-Breaking Science Presenter: Nickpreet Singh
3:22 pm: Discussion
Lead Discussant: Amit N. Vora
More information: www.tct2023.crfconnect.com; or www.crf.org
Follow DAIC’s TCT 2023 news coverage before, during and after the Conference.
Related coverage:
TCT 2023 Leadership Anticipates ‘Practice Changing’ Findings Ahead of 35th Scientific Symposium
CRF Announces TCT 2023 Late-breaking Clinical Trials
MedTech Innovation Forum Leads Day One at TCT 2023
Cardiovascular Research Foundation Announces Clinical Trials Center Executive Director