Association of serum copper (Cu) with cardiovascular mortality and all-cause mortality in a general population: a prospective cohort study

  • (WHO) WHO. Cardiovascular diseases (CVDs). 2017;2023.

  • Ding D, Lawson KD, Kolbe-Alexander TL, Finkelstein EA, Katzmarzyk PT, van Mechelen W, Pratt M. The economic burden of Physical Inactivity: a global analysis of major non-communicable Diseases. Lancet. 2016;388:1311–24.

    PubMed 

    Google Scholar 

  • Li Z, Fan Y, Tao C, Yan W, Huang Y, Qian H, Xu Q, Wan T, Chen Y, Qin Y, Lu C. Association between exposure to cadmium and risk of all-cause and cause-specific mortality in the general US adults: a prospective cohort study. Chemosphere. 2022;307:136060.

    CAS 
    PubMed 

    Google Scholar 

  • Yuan Y, Xiao Y, Feng W, Liu Y, Yu Y, Zhou L, Qiu G, Wang H, Liu B, Liu K, Yang H, Li X, Min X, Zhang C, Xu C, Zhang X, He M, Hu FB. Pan A and Wu T. plasma metal concentrations and Incident Coronary Heart Disease in Chinese adults: the Dongfeng-Tongji Cohort. Environ Health Perspect. 2017;125:107007.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Pierson H, Yang H, Lutsenko S. Copper Transport and Disease: what can we learn from Organoids? Annu Rev Nutr. 2019;39:75–94.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Karginova O, Weekley CM, Raoul A, Alsayed A, Wu T, Lee SS, He C, Olopade OI. Inhibition of Copper Transport induces apoptosis in Triple-negative Breast Cancer cells and suppresses Tumor Angiogenesis. Mol Cancer Ther. 2019;18:873–85.

    CAS 
    PubMed 

    Google Scholar 

  • Unsal YE, Soylak M, Tuzen M, Hazer B. Determination of lead, copper, and Iron in Cosmetics, Water, Soil, and Food using Polyhydroxybutyrate-B-polydimethyl Siloxane Preconcentration and Flame Atomic absorption spectrometry. Anal Lett. 2015;48:1163–79.

    CAS 

    Google Scholar 

  • Zhang S, Liu H, Amarsingh GV, Cheung CCH, Wu D, Narayanan U, Zhang L, Cooper GJS. Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked Heart Failure. Metallomics. 2020;12:259–72.

    CAS 
    PubMed 

    Google Scholar 

  • Zhang S, Liu H, Amarsingh GV, Cheung CC, Hogl S, Narayanan U, Zhang L, McHarg S, Xu J, Gong D, Kennedy J, Barry B, Choong YS, Phillips AR, Cooper GJ. Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. Cardiovasc Diabetol. 2014;13:100.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375:1254–61.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Huang L, Shen R, Huang L, Yu J, Rong H. Association between serum copper and Heart Failure: a meta-analysis. Asia Pac J Clin Nutr. 2019;28:761–9.

    CAS 
    PubMed 

    Google Scholar 

  • Chen X, Cai Q, Liang R, Zhang D, Liu X, Zhang M, Xiong Y, Xu M, Liu Q, Li P, Yu P, Shi A. Copper homeostasis and copper-induced cell death in the pathogenesis of Cardiovascular Disease and therapeutic strategies. Cell Death Dis. 2023;14:105.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhao H, Mei K, Hu Q, Wu Y, Xu Y, Qinling, Yu P, Deng Y, Zhu W, Yan Z, Liu X. Circulating copper levels and the risk of cardio-cerebrovascular diseases and cardiovascular and all-cause mortality: A systematic review and meta-analysis of longitudinal studies. Environmental Pollution.2023; 2023 Oct 16:122711.

  • Hu L, Bi C, Lin T, Liu L, Song Y, Wang P, Wang B, Fang C, Ma H, Huang X, Xu X, Zhang H, Guo H, Wang X, Bao H, Li J, Cheng X. Association between plasma copper levels and first Stroke: a community-based nested case-control study. Nutr Neurosci. 2022;25:1524–33.

    CAS 
    PubMed 

    Google Scholar 

  • Kunutsor SK, Dey RS, Laukkanen JA. Circulating serum copper is Associated with atherosclerotic Cardiovascular Disease, but not venous thromboembolism: a prospective cohort study. Pulse (Basel). 2021;9:109–15.

    PubMed 

    Google Scholar 

  • Khrisanopulo MP, ORIGIN, PROGRAM, AND OPERATION OF THE, U.S. NATIONAL HEALTH SURVEY. Vital Health Stat. 1963;1:1–41.

    Google Scholar 

  • Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41.

    CAS 
    PubMed 

    Google Scholar 

  • Whelton PK, Carey RM, Aronow WS, Casey DE Jr., Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC Jr., Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA, Sr., Williamson JD, Wright JT Jr, 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA. Prevention, detection, evaluation, and management of High Blood Pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice guidelines. J Am Coll Cardiol. 2018;71:2199–269.

    PubMed 

    Google Scholar 

  • Handelsman Y, Bloomgarden ZT, Grunberger G, Umpierrez G, Zimmerman RS, Bailey TS, Blonde L, Bray GA, Cohen AJ, Dagogo-Jack S, Davidson JA, Einhorn D, Ganda OP, Garber AJ, Garvey WT, Henry RR, Hirsch IB, Horton ES, Hurley DL, Jellinger PS, Jovanovič L, Lebovitz HE, LeRoith D, Levy P, McGill JB, Mechanick JI, Mestman JH, Moghissi ES, Orzeck EA, Pessah-Pollack R, Rosenblit PD, Vinik AI, Wyne K, Zangeneh F. American association of clinical endocrinologists and American college of endocrinology – clinical practice guidelines for developing a Diabetes Mellitus comprehensive care plan – 2015. Endocr Pract. 2015;21(Suppl 1):1–87.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Menke A, Casagrande S, Geiss L, Cowie CC. Prevalence of and trends in Diabetes among adults in the United States, 1988–2012. JAMA. 2015;314:1021–9.

    CAS 
    PubMed 

    Google Scholar 

  • Third Report of the National Cholesterol Education Program (NCEP). Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143–421.

    Google Scholar 

  • CDC. Laboratory procedure manual: zinc, copper and selenium. 2023; 2018.

  • Bellettiere J, LaMonte MJ, Evenson KR, Rillamas-Sun E, Kerr J, Lee IM, Di C, Rosenberg DE, Stefanick M, Buchner DM. Hovell MF and LaCroix AZ. Sedentary behavior and Cardiovascular Disease in older women: the Objective Physical Activity and Cardiovascular Health (OPACH) Study. Circulation. 2019;139:1036–46.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Park SY, Freedman ND, Haiman CA, Le Marchand L, Wilkens LR, Setiawan VW. Association of Coffee Consumption with Total and cause-specific mortality among nonwhite populations. Ann Intern Med. 2017;167:228–35.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Austin PC. Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Stat Med. 2009;28:3083–107.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Liu X, Tan Z, Huang Y, Zhao H, Liu M, Yu P, Ma J, Zhao Y, Zhu W, Wang J. Relationship between the triglyceride-glucose index and risk of Cardiovascular Diseases and mortality in the general population: a systematic review and meta-analysis. Cardiovasc Diabetol. 2022;21:1–17.

    CAS 

    Google Scholar 

  • CDC. Vital and Health Statistics. 2023.

  • Marniemi J, Järvisalo J, Toikka T, Räihä I, Ahotupa M, Sourander L. Blood vitamins, mineral elements and inflammation markers as risk factors of vascular and non-vascular Disease mortality in an elderly population. Int J Epidemiol. 1998;27:799–807.

    CAS 
    PubMed 

    Google Scholar 

  • Shi L, Yuan Y, Xiao Y, Long P, Li W, Yu Y, Liu Y, Liu K, Wang H, Zhou L, Yang H, Li X, He M, Wu T. Associations of plasma metal concentrations with the risks of all-cause and Cardiovascular Disease mortality in Chinese adults. Environ Int. 2021;157:106808.

    CAS 
    PubMed 

    Google Scholar 

  • Tonelli M, Wiebe N, Bello A, Field CJ, Gill JS, Hemmelgarn BR, Holmes DT, Jindal K, Klarenbach SW, Manns BJ, Thadhani R, Kinniburgh D. Concentrations of Trace Elements and Clinical outcomes in Hemodialysis patients: a prospective cohort study. Clin J Am Soc Nephrol. 2018;13:907–15.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Grammer TB, Kleber ME, Silbernagel G, Pilz S, Scharnagl H, Lerchbaum E, Tomaschitz A, Koenig W, März W. Copper, ceruloplasmin, and long-term cardiovascular and total mortality (the Ludwigshafen Risk and Cardiovascular Health Study). Free Radic Res. 2014;48:706–15.

    CAS 
    PubMed 

    Google Scholar 

  • Leone N, Courbon D, Ducimetiere P, Zureik M. Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiol (Cambridge Mass). 2006;17:308–14.

    Google Scholar 

  • Wu T, Sempos CT, Freudenheim JL, Muti P, Smit E. Serum iron, copper and zinc concentrations and risk of cancer mortality in US adults. Ann Epidemiol. 2004;14:195–201.

    PubMed 

    Google Scholar 

  • Eshak ES, Iso H, Yamagishi K, Maruyama K, Umesawa M, Tamakoshi A. Associations between copper and zinc intakes from diet and mortality from Cardiovascular Disease in a large population-based prospective cohort study. J Nutr Biochem. 2018;56:126–32.

    CAS 
    PubMed 

    Google Scholar 

  • Tsuboi A, Terazawa Watanabe M, Kazumi T, Fukuo K. Serum copper, zinc and risk factors for Cardiovascular Disease in community-living Japanese elderly women. Asia Pac J Clin Nutr. 2014;23:239–45.

    CAS 
    PubMed 

    Google Scholar 

  • Bleys J, Navas-Acien A, Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch Intern Med. 2008;168:404–10.

    CAS 
    PubMed 

    Google Scholar 

  • Li Q, Chen Q, Zhang H, Xu Z, Wang X, Pang J, Ma J, Ling W, Li D. Associations of serum magnesium levels and calcium-magnesium ratios with mortality in patients with coronary artery Disease. Diabetes Metab. 2020;46:384–91.

    CAS 
    PubMed 

    Google Scholar 

  • Isiozor NM, Kunutsor SK, Vogelsang D, Isiozor I, Kauhanen J, Laukkanen JA. Serum copper and the risk of Cardiovascular Disease death in Finnish men. Nutr Metab Cardiovasc Dis. 2023;33:151–7.

    CAS 
    PubMed 

    Google Scholar 

  • Chen L, Min J, Wang F. Copper homeostasis and cuproptosis in health and Disease. Signal Transduct Target Ther. 2022;7:378.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gralla EB, Valentine JS. Null mutants of Saccharomyces cerevisiae Cu,Zn superoxide dismutase: characterization and spontaneous mutation rates. J Bacteriol. 1991;173:5918–20.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Elchuri S, Oberley TD, Qi W, Eisenstein RS, Jackson Roberts L, Van Remmen H, Epstein CJ, Huang TT. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene. 2005;24:367–80.

    CAS 
    PubMed 

    Google Scholar 

  • Bertinato J, L’Abbé MR. Copper modulates the degradation of copper chaperone for Cu,Zn superoxide dismutase by the 26 S proteosome. J Biol Chem. 2003;278:35071–8.

    CAS 
    PubMed 

    Google Scholar 

  • Chen Z, Zhu J, Zhou H, Jia Y, Ruan H, Diao Q, Li M, Zheng L, Yao S, Guo Y, Zhou Y, Jiang Y. The involvement of copper, circular RNAs, and inflammatory cytokines in chronic Respiratory Disease. Chemosphere. 2022;303:135005.

    CAS 
    PubMed 

    Google Scholar 

  • Takao T, Yanagisawa H, Suka M, Yoshida Y, Onishi Y, Tahara T, Kikuchi T, Kushiyama A, Anai M, Takahashi K, Wakabayashi Sugawa S, Yamazaki H, Kawazu S, Iwamoto Y, Noda M, Kasuga M. Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic Kidney Disease in patients with type 2 Diabetes: the Asahi Diabetes Complications Study. J Diabetes Investig. 2022;13:299–307.

    CAS 
    PubMed 

    Google Scholar 

  • Choo XY, Alukaidey L, White AR, Grubman A. Neuroinflammation and copper in Alzheimer’s Disease. Int J Alzheimers Dis. 2013;2013:145345.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Pereira TC, Campos MM, Bogo MR. Copper toxicology, oxidative stress and inflammation using zebrafish as experimental model. J Appl Toxicol. 2016;36:876–85.

    CAS 
    PubMed 

    Google Scholar 

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