Ouyang A, Locke GR 3. rd. Overview of neurogastroenterology-gastrointestinal motility and functional GI disorders: classification, prevalence, and epidemiology. Gastroenterol Clin North Am. 2007;36:485 – 98, vii.
Mittal R, Vaezi MF. Esophageal motility Disorders and gastroesophageal reflux disease. N Engl J Med. 2020;383:1961–72.
Google Scholar
Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, et al. Paediatric intestinal pseudo-obstruction: evidence and Consensus-based Recommendations from an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018;66:991–1019.
Google Scholar
De Giorgio R, Ricciardiello L, Naponelli V, Selgrad M, Piazzi G, Felicani C et al. Chronic intestinal pseudo-obstruction related to viral infections. Transplant Proc. 2010;42:9–14.
Camilleri M. Gastrointestinal motility disorders in neurologic disease. J Clin Invest. 2021;131.
Black CJ, Drossman DA, Talley NJ, Ruddy J, Ford AC. Functional gastrointestinal disorders: advances in understanding and management. Lancet. 2020;396:1664–74.
Google Scholar
Nurko S. Motility Disorders in Children. Pediatr Clin North Am. 2017;64:593–612.
Google Scholar
Ford AC, Mahadeva S, Carbone MF, Lacy BE, Talley NJ. Functional dyspepsia. Lancet. 2020;396:1689–702.
Google Scholar
Vaezi MF, Pandolfino JE, Yadlapati RH, Greer KB, Kavitt RT. ACG clinical guidelines: diagnosis and management of Achalasia. Am J Gastroenterol. 2020;115:1393–411.
Google Scholar
Nehra AK, Sheedy SP, Johnson CD, Flicek KT, Venkatesh SK, Heiken JP, et al. Imaging Rev Gastrointest Motil Disorders Radiographics. 2022;42:2014–36.
Brun P, Qesari M, Marconi PC, Kotsafti A, Porzionato A, Macchi V, et al. Herpes simplex virus type 1 infects enteric neurons and triggers gut dysfunction via macrophage recruitment. Front Cell Infect Microbiol. 2018;8:74.
Google Scholar
Naik RD, Vaezi MF, Gershon AA, Higginbotham T, Chen JJ, Flores E, et al. Association of Achalasia with active varicella zoster virus infection of the Esophagus. Gastroenterology. 2021;161:719–21e2.
Google Scholar
Ye L, Bae M, Cassilly CD, Jabba SV, Thorpe DW, Martin AM et al. Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Cell Host Microbe. 2021;29:179 – 96.e9.
Geng ZH, Zhu Y, Li QL, Zhao C, Zhou PH. Enteric nervous system: the Bridge between the Gut Microbiota and Neurological Disorders. Front Aging Neurosci. 2022;14:810483.
Google Scholar
Rao M, Gershon MD. The bowel and beyond: the enteric nervous system in neurological disorders. Nat Rev Gastroenterol Hepatol. 2016;13:517–28.
Google Scholar
Lake JI, Heuckeroth RO. Enteric nervous system development: migration, differentiation, and disease. Am J Physiol Gastrointest Liver Physiol. 2013;305:G1–24.
Google Scholar
Giuffre M, Moretti R, Campisciano G, da Silveira ABM, Monda VM, Comar M et al. You talking to me? Says the enteric nervous system (ENS) to the microbe. How intestinal microbes interact with the ENS. J Clin Med. 2020;9.
Pawolski V, Schmidt MHH. Neuron-Glia Interaction in the developing and adult enteric nervous system. Cells. 2020;10.
Ngwainmbi J, De DD, Smith TH, El-Hage N, Fitting S, Kang M, et al. Effects of HIV-1 Tat on enteric neuropathogenesis. J Neurosci. 2014;34:14243–51.
Google Scholar
Brun P, Scarpa M, Marchiori C, Conti J, Kotsafti A, Porzionato A, et al. Herpes simplex virus type 1 engages toll like receptor 2 to Recruit Macrophages during infection of enteric neurons. Front Microbiol. 2018;9:2148.
Google Scholar
Gershon AA, Chen J, Gershon MD. Use of Saliva to identify varicella zoster virus infection of the gut. Clin Infect Dis. 2015;61:536–44.
Google Scholar
Marasco G, Lenti MV, Cremon C, Barbaro MR, Stanghellini V, Di Sabatino A, et al. Implications of SARS-CoV-2 infection for neurogastroenterology. Neurogastroenterol Motil. 2021;33:e14104.
Google Scholar
Goldstein RS, Kinchington PR. Varicella zoster virus neuronal latency and Reactivation Modeled in Vitro. Curr Top Microbiol Immunol. 2023;438:103–34.
Google Scholar
Kennedy PG, Rovnak J, Badani H, Cohrs RJ. A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation. J Gen Virol. 2015;96:1581–602.
Google Scholar
Gershon AA, Chen J, Gershon MD. A model of lytic, latent, and reactivating varicella-zoster virus infections in isolated enteric neurons. J Infect Dis. 2008;197(Suppl 2):61–5.
Chen JJ, Gershon AA, Li Z, Cowles RA, Gershon MD. Varicella zoster virus (VZV) infects and establishes latency in enteric neurons. J Neurovirol. 2011;17:578–89.
Google Scholar
Gan L, Wang M, Chen JJ, Gershon MD, Gershon AA. Infected peripheral blood mononuclear cells transmit latent varicella zoster virus infection to the guinea pig enteric nervous system. J Neurovirol. 2014;20:442–56.
Google Scholar
Chen JJ, Gershon AA, Li ZS, Lungu O, Gershon MD. Latent and lytic infection of isolated guinea pig enteric ganglia by varicella zoster virus. J Med Virol. 2003;70(Suppl 1):71–8.
Brun P, Conti J, Zatta V, Russo V, Scarpa M, Kotsafti A, et al. Persistent herpes simplex virus type 1 infection of enteric neurons triggers CD8(+) T cell response and gastrointestinal neuromuscular dysfunction. Front Cell Infect Microbiol. 2021;11:615350.
Google Scholar
Amlie-Lefond C, Gilden D. Varicella Zoster Virus: A Common cause of stroke in children and adults. J Stroke Cerebrovasc Dis. 2016;25:1561–9.
Google Scholar
Wilson AC, Mohr I. A cultured affair: HSV latency and reactivation in neurons. Trends Microbiol. 2012;20:604–11.
Google Scholar
Gershon AA, Chen J, Davis L, Krinsky C, Cowles R, Reichard R, et al. Latency of varicella zoster virus in dorsal root, cranial, and enteric ganglia in vaccinated children. Trans Am Clin Climatol Assoc. 2012;123:17–33. discussion – 5.
Google Scholar
Gershon MD, Gershon AA. VZV infection of keratinocytes: production of cell-free infectious virions in vivo. Curr Top Microbiol Immunol. 2010;342:173–88.
Google Scholar
Gesser RM, Koo SC. Oral inoculation with herpes simplex virus type 1 infects enteric neuron and mucosal nerve fibers within the gastrointestinal tract in mice. J Virol. 1996;70:4097–102.
Google Scholar
Guedia J, Brun P, Bhave S, Fitting S, Kang M, Dewey WL, et al. HIV-1 Tat exacerbates lipopolysaccharide-induced cytokine release via TLR4 signaling in the enteric nervous system. Sci Rep. 2016;6:31203.
Google Scholar
Gesser RM, Valyi-Nagy T, Altschuler SM, Fraser NW. Oral-oesophageal inoculation of mice with herpes simplex virus type 1 causes latent infection of the vagal sensory ganglia (nodose ganglia). J Gen Virol. 1994;75(Pt 9):2379–86.
Google Scholar
Julio-Pieper M, López-Aguilera A, Eyzaguirre-Velásquez J, Olavarría-Ramírez L, Ibacache-Quiroga C, Bravo JA et al. Gut susceptibility to viral Invasion: contributing roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation. Int J Mol Sci. 2021;22.
Narita M, Kimura K, Tanimura N, Arai S, Uchimura A. Immunohistochemical demonstration of spread of Aujeszky’s disease virus to the porcine central nervous system after intestinal inoculation. J Comp Pathol. 1998;118:329–36.
Google Scholar
Pfannkuche H, Konrath A, Buchholz I, Richt JA, Seeger J, Müller H, et al. Infection of the enteric nervous system by Borna disease virus (BDV) upregulates expression of calbindin D-28k. Vet Microbiol. 2008;127:275–85.
Google Scholar
Khoury-Hanold W, Yordy B, Kong P, Kong Y, Ge W, Szigeti-Buck K, et al. Viral spread to enteric neurons links genital HSV-1 infection to toxic megacolon and lethality. Cell Host Microbe. 2016;19:788–99.
Google Scholar
Gershon M, Gershon A. Varicella-Zoster Virus and the enteric nervous system. J Infect Dis. 2018;218:113–s9.
Ku CC, Padilla JA, Grose C, Butcher EC, Arvin AM. Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers. J Virol. 2002;76:11425–33.
Google Scholar
Sen N, Mukherjee G, Sen A, Bendall SC, Sung P, Nolan GP, et al. Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus. Cell Rep. 2014;8:633–45.
Google Scholar
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271 – 80.e8.
Fenrich M, Mrdenovic S, Balog M, Tomic S, Zjalic M, Roncevic A, et al. SARS-CoV-2 dissemination through peripheral nerves explains multiple Organ Injury. Front Cell Neurosci. 2020;14:229.
Google Scholar
Kariyawasam JC, Jayarajah U, Riza R, Abeysuriya V, Seneviratne SL. Gastrointestinal manifestations in COVID-19. Trans R Soc Trop Med Hyg. 2021;115:1362–88.
Google Scholar
Shinu P, Morsy MA, Deb PK, Nair AB, Goyal M, Shah J, et al. SARS CoV-2 Organotropism Associated Pathogenic Relationship of Gut-Brain Axis and Illness. Front Mol Biosci. 2020;7:606779.
Google Scholar
Esposito G, Pesce M, Seguella L, Sanseverino W, Lu J, Sarnelli G. Can the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion? Brain Behav Immun. 2020;87:93–4.
Google Scholar
Spencer NJ, Hu H. Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility. Nat Rev Gastroenterol Hepatol. 2020;17:338–51.
Google Scholar
Ra SH, Kwon JS, Kim JY, Cha HH, Lee HJ, Jung J, et al. Frequency of putative enteric zoster diagnosed using saliva samples in patients with abdominal pain: a prospective study. Infect Dis (Lond). 2021;53:713–8.
Google Scholar
Cipriani G, Gibbons SJ, Kashyap PC, Farrugia G. Intrinsic gastrointestinal macrophages: their phenotype and role in gastrointestinal motility. Cell Mol Gastroenterol Hepatol. 2016;2:120–30.e1.
Google Scholar
Brun P, Giron MC, Zoppellaro C, Bin A, Porzionato A, De Caro R, et al. Herpes simplex virus type 1 infection of the rat enteric nervous system evokes small-bowel neuromuscular abnormalities. Gastroenterology. 2010;138:1790–801.
Google Scholar
Barbara G, Cremon C, Pallotti F, De Giorgio R, Stanghellini V, Corinaldesi R. Postinfectious irritable bowel syndrome. J Pediatr Gastroenterol Nutr. 2009;48(Suppl 2):95–7.
Egan KP, Wu S, Wigdahl B, Jennings SR. Immunological control of herpes simplex virus infections. J Neurovirol. 2013;19:328–45.
Google Scholar
Braun J. Flaviviruses hit a moving target. Cell. 2018;175:1175–6.
Google Scholar
Facco M, Brun P, Baesso I, Costantini M, Rizzetto C, Berto A, et al. T cells in the myenteric plexus of achalasia patients show a skewed TCR repertoire and react to HSV-1 antigens. Am J Gastroenterol. 2008;103:1598–609.
Google Scholar
Mohammed FS, Krogel N. Post-COVID-19 Achalasia? Dig Dis Sci. 2023;68:333–4.
Google Scholar
Gaber CE, Cotton CC, Eluri S, Lund JL, Farrell TM, Dellon ES. Autoimmune and viral risk factors are associated with achalasia: a case-control study. Neurogastroenterol Motil. 2022;34:e14312.
Google Scholar
Robertson CS, Martin BA, Atkinson M. Varicella-zoster virus DNA in the oesophageal myenteric plexus in achalasia. Gut. 1993;34:299–302.
Google Scholar
Boeckxstaens GE. Achalasia: virus-induced euthanasia of neurons? Am J Gastroenterol. 2008;103:1610–2.
Google Scholar
Kahrilas PJ, Boeckxstaens G. The spectrum of achalasia: lessons from studies of pathophysiology and high-resolution manometry. Gastroenterology. 2013;145:954–65.
Google Scholar
Jia X, Chen S, Zhuang Q, Tan N, Zhang M, Cui Y, et al. Achalasia: the current clinical dilemma and possible pathogenesis. J Neurogastroenterol Motil. 2023;29:145–55.
Google Scholar
Amin I, Younas S, Afzal S, Shahid M, Idrees M. Herpes simplex virus type 1 and host antiviral Immune responses: an update. Viral Immunol. 2019;32:424–9.
Google Scholar
Zhang F, Lau RI, Liu Q, Su Q, Chan FKL, Ng SC. Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications. Nat Rev Gastroenterol Hepatol. 2023;20:323–37.
Google Scholar
Nagata N, Takeuchi T, Masuoka H, Aoki R, Ishikane M, Iwamoto N, et al. Human gut microbiota and its metabolites Impact Immune responses in COVID-19 and its complications. Gastroenterology. 2023;164:272–88.
Google Scholar
Zuo T, Wu X, Wen W, Lan P. Gut microbiome alterations in COVID-19. Genomics Proteom Bioinf. 2021;19:679–88.
Dhar D, Mohanty A. Gut microbiota and Covid-19- possible link and implications. Virus Res. 2020;285:198018.
Google Scholar
Yeoh YK, Zuo T, Lui GC, Zhang F, Liu Q, Li AY, et al. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut. 2021;70:698–706.
Google Scholar
Ben Haij N, Leghmari K, Planès R, Thieblemont N, Bahraoui E. HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-α and IL-10. Retrovirology. 2013;10:123.
Google Scholar
Anitha M, Vijay-Kumar M, Sitaraman SV, Gewirtz AT, Srinivasan S. Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling. Gastroenterology. 2012;143:1006-16.e4.
Planès R, Ben Haij N, Leghmari K, Serrero M, BenMohamed L, Bahraoui E. HIV-1 Tat protein activates both the MyD88 and TRIF pathways to induce tumor necrosis factor alpha and Interleukin-10 in human monocytes. J Virol. 2016;90:5886–98.
Google Scholar
Galligan JJ. HIV, opiates, and enteric neuron dysfunction. Neurogastroenterol Motil. 2015;27:449–54.
Google Scholar
White JP, Xiong S, Malvin NP, Khoury-Hanold W, Heuckeroth RO, Stappenbeck TS et al. Intestinal dysmotility syndromes following systemic infection by Flaviviruses. Cell. 2018;175:1198 – 212.e12.