Adding vancomycin to beta-lactam prophylaxis with cefazolin did not help prevent surgical-site infections in patients undergoing arthroplasty mostly for the knees or hips, a randomized trial showed. In over 4,000 patients without known methicillin-resistant Staphylococcus aureus (MRSA) colonization, surgical-site infections at 90 days occurred in 4.5% of those who received the combination compared with 3.5% […]
October 18, 2023 1 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . <button type="button" class="btn btn-primary" data-loading-text="Loading ” data-action=”subscribe”> Subscribe Added to email alerts We were unable to process your request. […]
Abstract Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we show that Calpeptin is an extremely potent cysteine cathepsin inhibitor, a finding additionally supported by X-ray crystallography. Cell infection […]
Abstract Non-alcoholic fatty liver disease (NAFLD), specifically liver steatosis and fibrosis with steatohepatitis (NASH), is often associated with visceral adiposopathy, whose pathogenetic features have been proposed as tumorigenic triggers. We performed a prospective analysis in 653 metabolic women to reveal any conditions that may predict and concur to cancer development during a 8-years period of […]
Bryan Christie Edinburgh Between 95 000 and 167 000 patients are estimated to have caught covid-19 in England’s hospitals during the second wave of the pandemic while being treated for other problems. A study reported in Nature used data from 356 English hospitals, representing almost all NHS general and acute care beds, to calculate the extent of […]
In this study, 32 final-year medical students in the internship phase were invited to participate in the interviews, of whom 15 individuals (47%) participated in the interviews. Among the participants, 13 individuals were aged between 24 and 29 years, and 2 individuals were aged between 30 and 35 years, with a mean age of 28.8 […]
Abstract Hospital-based transmission had a dominant role in Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) epidemics1,2, but large-scale studies of its role in the SARS-CoV-2 pandemic are lacking. Such transmission risks spreading the virus to the most vulnerable individuals and can have wider-scale impacts through hospital–community interactions. Using data […]
