Monthly Archives: October 2023
Oct
Abstract Rare Mendelian disorders pose a major diagnostic challenge and collectively affect 300–400 million patients worldwide. Many automated tools aim to uncover causal genes in patients with suspected genetic disorders, but evaluation of these tools is limited due to the lack of comprehensive benchmark datasets that include previously unpublished conditions. Here, we present a computational […]
Oct
Abstract Mpox virus (MPXV) primarily infects human skin to cause lesions. Currently, robust models that recapitulate skin infection by MPXV are lacking. Here we demonstrate that human induced pluripotent stem cell-derived skin organoids are susceptible to MPXV infection and support infectious virus production. Keratinocytes, the predominant cell type of the skin epithelium, effectively support MPXV […]
Oct
October 12, 2023 1 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . <button type="button" class="btn btn-primary" data-loading-text="Loading ” data-action=”subscribe”> Subscribe Added to email alerts We were unable to process your request. […]
“Most previous studies have shown that racial or ethnic minority groups are exposed to disproportionately high levels of PM2.5. However, the racial and ethnic disparities in PM2.5-attributable mortality burden cannot be fully explained by the disparities in exposure, because vulnerability can also vary across racial groups”, explains Kai Chen, the corresponding author and an assistant […]
Oct
Manion, J. et al. Nature https://doi.org/10.1038/s41586-023-06607-2 (2023). Article PubMed Google Scholar Kelly, C. P. & LaMont, J. T. N. Engl. J. Med. 359, 1932–1940 (2008). Article PubMed Google Scholar Aktories, K., Schwan, C. & Jank, T. Annu. Rev. Microbiol. 71, 281–307 (2017). Article PubMed Google Scholar Chiu, I. M., von Hehn, C. A. & Woolf, […]
Cancer and neoplasms
Rethinking placebos: embracing synthetic control arms in clinical trials for rare tumors
Oct
External comparator arms should be used when investigating novel therapies for gastrointestinal stromal tumor and other rare tumors to facilitate drug testing and regulatory approvals. Rare cancers, although individually uncommon, account for approximately one-quarter of all malignancies. Population-based studies have consistently shown that patients with rare cancers have worse outcomes than those diagnosed with more […]
Oct
In conjunction with updated guidelines on red blood cell transfusion, JAMA has published a special issue on blood, bleeding, and transfusion. In addition to the 2023 Association for the Advancement of Blood & Biotherapies (AABB) international guidelines, published as a “special communication,” the journal published two papers evaluating transfusion practices in the intensive care unit […]
Oct
News Photo by Mike Gonzalez Rite Aid pharmacist Alivia McDonald administers a Moderna COVID-19 vaccine to a customer at the U.S.-23 South location on Wednesday. ALPENA — Confirmed COVID-19 infections have increased within the past 40 days in Alpena, Montmorency, and Presque Isle counties. State data shows Alpena County had 61 confirmed infections since Sept. […]