Monthly Archives: October 2023

Infection

An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models

Posted on by yun
24
Oct

Abstract A pan-sarbecovirus or pan-betacoronavirus vaccine that can prevent current and potential future beta-coronavirus infections is important for fighting possible future pandemics. Here, we report a mucosal vaccine that cross-protects small animal models from sarbecoviruses including SARS-CoV-1, SARS-CoV-2 and its variants. The vaccine comprises a live-but-defective SARS-CoV-2 virus that is envelope deficient and has the […]

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Infection

Major study shows new insights into lasting impacts of COVID‐19 on UK population | Imperial News

Posted on by yun
24
Oct

Tens of thousands of people in England may have lasting symptoms from COVID‐19 more than a year after infection, new analysis reveals. The findings come from a representative sample of more than a quarter of a million people in England surveyed as part of the REACT study, who self-reported their symptoms and the impact of […]

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Cardiovascular

Late-Breaking Data Showcase the Benefits of Abbott’s Minimally Invasive Devices for People With Leaky Heart Valves

Posted on by yun
24
Oct

Late-Breaking Data Showcase the Benefits of Abbott’s Minimally Invasive Devices for People With Leaky Heart Valves New data presented at Transcatheter Cardiovascular Therapeutics (TCT) 2023 from the TRILUMINATE™ pivotal trial confirm safety, effectiveness and improvements in quality of life when treating tricuspid regurgitation (a leaky valve) with TriClip™, an investigational device in the U.S. One-year outcomes […]

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Blood

Four tips to maintain iron balance for blood donors

Posted on by yun
24
Oct

Low hemoglobin is the #1 deferral reason Low hemoglobin or hematocrit has sometimes been referred to as “low iron” although this term is not entirely accurate. The most common cause for low hematocrit is iron deficiency, but there are other causes. Iron deficiency can cause fatigue, weakness and even anemia. To ensure the well-being of […]

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Cancer and neoplasms

Anti-tumor activity of a recombinant measles virus against canine lung cancer cells

Posted on by yun
24
Oct

Abstract Canine primary lung cancer with metastasis has a poor prognosis with no effective treatment. We previously generated a recombinant measles virus (MV) that lost binding affinity to a principal receptor, SLAM, to eliminate its virulence as a new cancer treatment strategy. The virus, rMV-SLAMblind, targets nectin-4, recently listed as a tumor marker, and exerts […]

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Congenital disorders

Host fecal DNA specific methylation signatures mark gut dysbiosis and inflammation in children affected by autism spectrum disorder

Posted on by yun
24
Oct

Abstract The gut-brain axis involves several bidirectional pathway communications including microbiome, bacterial metabolites, neurotransmitters as well as immune system and is perturbed both in brain and in gastrointestinal disorders. Consistently, microbiota-gut-brain axis has been found altered in autism spectrum disorder (ASD). We reasoned that such alterations occurring in ASD may impact both on methylation signatures […]

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Cardiovascular

Helping People With Serious Mental Illness Quit Smoking

Posted on by yun
24
Oct

October 24, 2023 • Research Highlight People with serious mental illness (SMI), such as schizophrenia, bipolar disorder, and major depression, often face significant physical health challenges. For example, people with SMI die from cardiovascular disease at twice the rate of those without SMI, and levels of tobacco smoking in this population are high. Although smoking […]

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Congenital disorders

RWJBarnabas Health Honored by Becker’s as One of Nation’s Top Orthopedic Programs

Posted on by yun
24
Oct

RWJBarnabas Health has been named among Becker’s Hospital Review’s 100 Hospitals and Health Systems with Great Orthopedic Programs for 2023. The list celebrates the nation’s leading providers of orthopedic care and orthopedic programs that offer minimally invasive treatments, forward-thinking research, and breakthrough clinical trials that drastically improve patient outcomes. RWJBarnabas Health offers comprehensive orthopedic services […]

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