Cancer and neoplasms
Vactosertib by MedPacto for Gastric Cancer: Likelihood of Approval
Nov
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Vactosertib overview
Vactosertib (TEW-7197) is under development for the treatment of advanced solid tumors including melanoma, breast cancer, hepatocellular carcinoma, metastatic non-small cell lung cancer, prostate cancer, chronic myelocytic leukemia, myelodysplastic syndrome, metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma, adenocarcinoma of the gastroesophageal junction, esophageal adenocarcinoma, glioblastoma multiforme, gastric cancer, pancreatic cancer, desmoid sarcoma, metastatic urothelial bladder carcinoma including renal pelvis cancer, ureters cancer, urinary bladder cancer, refractory acute myeloid leukemia, relapsed acute myeloid leukemia, acute lymphoblastic lymphoma, non-Hodgkin lymphoma, Hodgkin lymphoma and urethral cancer, myeloproliferative neoplasm and colon cancer. The drug candidate is administered orally as a tablet. It acts by inhibiting protein serine/threonine kinase activity of transforming growth factor (TGF)-beta receptor type 1 (TGFBR1, ALK5). It was also under development for refractory and relapsed multiple myeloma, hepatic fibrosis, renal fibrosis, pulmonary fibrosis.
MedPacto overview
MedPacto, a subsidiary of Theragen Etex Co Ltd, is a biotechnology company that discovers and develops therapies to treat cancer and autoimmune diseases. Its product pipeline comprise Vactosertib drug, to treat gastric and pancreatic cancer, desmoid sarcoma, colorectal and bladder cancer, non-small cell lung carcinoma (NSCLC), multiple myeloma and myeloproliferative neoplasms. The company is also investigating MA-B2, MPD-001, MPD-002 and MPD-003 against solid tumors; MU-D201, to treat diffuse large B-cell lymphoma (DLBCL); and also MI-S4 for nonalcoholic steatohepatitis (NASH). It works in partnership with pharmaceutical companies including Merck and AstraZeneca Plc. MedPacto is headquartered in Seoul, South Korea.
For a complete picture of Vactosertib’s drug-specific PTSR and LoA scores, buy the report here.
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