OCEANIC-AF Trial Sunk; Second Renal Denervation Device Approved; Strep-Stroke Link?

Bayer announced that the phase III OCEANIC-AF study of the oral factor XIa inhibitor asundexian was stopped early due to inferior efficacy compared with apixaban (Eliquis) for patients with atrial fibrillation (Afib).

The CDC reported that the age-adjusted prevalence of hypertension climbed to 44.2% in Los Angeles County and 47.3% across the U.S. from 2015 to 2018.

High-sensitivity cardiac troponin I helped predict preeclampsia in pregnant women. (Circulation)

Abnormal cardiac findings were highly prevalent in the aftermath of multisystem inflammatory disease in children, whether the patient had acute myocardial injury during hospitalization or not. (Pediatrics)

The Symplicity Spyral radiofrequency-based system from Medtronic became the second renal denervation system to be FDA-approved for the treatment of hypertension.

Medtronic also announced that its PulseSelect pulsed field ablation system and Nitron CryoConsole received the CE Mark for treating Afib.

The FDA granted 510(k) clearance to Arineta’s artificial intelligence-powered deep learning image reconstruction technology with the Spotlight cardiovascular CT scanners, the company announced.

Over two decades, hypertension became increasingly common in low-income middle-age adults, while higher-income peers were more likely to have diabetes and obesity. (Annals of Internal Medicine)

People with low incomes tended to have less cardiologist involvement during a hospitalization for heart failure. (JAMA Network Open)

In transthyretin amyloid cardiomyopathy, tafamidis (Vyndaqel, Vyndamax) attenuated the decline in cardiac function in a post hoc analysis of the ATTR-ACT trial. (JAMA Cardiology)

Plenty of people in the real world would not meet the TRILUMINATE trial eligibility criteria for transcatheter tricuspid edge-to-edge repair. (JACC: Cardiovascular Interventions)

Progression and regression are both possible with early subclinical atherosclerosis in asymptomatic individuals. (Journal of the American College of Cardiology)

A flexible 0.5-mm Pb equivalent x-ray shield blocked a significant amount of operator radiation exposure during cardiac catheterization. (Circulation: Cardiovascular Interventions)

In valve-sparing aortic root replacement, concomitant leaflet repair and bicuspid valve disease were the only predictors identified for long-term re-intervention. (Journal of Thoracic and Cardiovascular Surgery)

A case report describing commotio cordis leading to cardiac arrest in a basketball player was backed by ECG and video evidence. (Heart Rhythm Case Reports)

Soccer player Raphael Dwamena collapsed and died during a match in Albania, and his cardiologist attributed this to the player’s decision to remove an implantable cardioverter-defibrillator placed for a “serious ventricular arrhythmia.” (Daily Mail)

The health benefits of swapping out animal-based food for plant-based food were quantified in a systematic review. (BMC Medicine)

Might thrombogenic viridans streptococci bacteria play a role in the pathophysiology of ischemic stroke? (Journal of the American Heart Association)

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