Active Pharmaceutical Ingredient Types for Cardiovascular Research

Cardiovascular disease is a serious threat to human life and health. Reasonable prevention and drug treatment are the cornerstones of tackling cardiovascular disease. Cardiovascular APIs are main components of drugs used to treat diseases of the cardiovascular system, including lipid-lowering drugs, anti-heart failure drugs, anti-arrhythmic drugs, anti-hypertensive drugs, anti-anginal drugs and other chemical drugs. 

Antihypertensive Series

There are many types of antihypertensive drugs, and different types of drugs have different curative effects on different types of hypertension. Antihypertensive drugs mainly affect blood pressure by affecting the sympathetic nervous system, the renin-angiotensin-aldosterone system and the endothelin system. Physiological regulation plays an important role in the system to play a hypotensive effect.

Antianginal Series

Anti-anginal drugs mainly reduce myocardial oxygen consumption by dilating blood vessels, slowing heart rate, and reducing left ventricular end-diastolic volume; increasing myocardial oxygen supply by dilating coronary arteries, promoting collateral circulation, opening and promoting blood redistribution; Lipid metabolism is transformed into glucose metabolism to improve myocardial metabolism and inhibit platelet aggregation and thrombus formation. Commonly used drugs are nitrates, β-receptor blockers, calcium channel blockers, antiplatelet drugs and angiotensin Ⅰ converting enzyme inhibitors.

Anti-heart Failure Series

Heart failure is an obstructive disease of cardiac insufficiency, which generally manifests as reduced or impaired myocardial contractile function, resulting in reduced cardiac output and reduced blood supply for oxygen supply and metabolism of body tissues, resulting in heart failure. Drugs for the treatment of heart failure can generally be divided into cardiac glycosides (positive inotropic drugs), non-cardiac glycosides (such as ACE inhibitors, angiotensin II receptor antagonist ARB, β-receptor blockers, diuretics and calcium channel blockers).

Antiarrhythmic Series

Antiarrhythmic drugs are a class of drugs used to treat heart rhythm disorders. With the understanding of the electrophysiological properties of the heart and the mechanism of action of antiarrhythmic drugs, the drug treatment of arrhythmias has made great progress.

Lipid-lowering Series

Lipid-lowering drugs refer to drugs that lower blood lipid levels. The body’s plasma contains a wide variety of neutral fats (triglycerides, cholesterol) and lipids (phospholipids, lipids, sterols, steroids) known as blood lipids. Commonly used lipid-lowering drugs mainly include statins, fibrates, and niacin.