Association of body mass index and long-term mortality in patients from nationwide LIPIDOGRAM 2004–2015 cohort studies: no obesity paradox?

  • Kenchaiah S, Evans JC, Levy D, et al. Obesity and the risk of heart failure. N Engl J Med. 2002;347(5):59–60. https://doi.org/10.1056/NEJMOA020245.

    Article 

    Google Scholar 

  • Manson JE, Colditz GA, Stampfer MJ, et al. A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med. 2010;322(13):882–9. https://doi.org/10.1056/NEJM199003293221303.

    Article 

    Google Scholar 

  • Yousufuddin M, Takahashi PY, Major B, et al. Association between hyperlipidemia and mortality after incident acute myocardial infarction or acute decompensated heart failure: a propensity score matched cohort study and a meta-analysis. BMJ Open. 2019;9(12):1–12. https://doi.org/10.1136/bmjopen-2018-028638.

    Article 

    Google Scholar 

  • Janssen I, Mark AE. Elevated body mass index and mortality risk in the elderly. Obes Rev. 2007;8(1):41–59. https://doi.org/10.1111/J.1467-789X.2006.00248.X.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ. 2007;335(7630):1134–9. https://doi.org/10.1136/BMJ.39367.495995.AE.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Banach M, Burchardt P, Chlebus K, et al. WYTYCZNE PTL/KLRwP/PTK/ PTDL/PTD/PTNT DIAGNOSTYKI I LECZENIA ZABURZEŃ LIPIDOWYCH W POLSCE 2021. Lekarz POZ Suplement. Published online 2021. https://www.termedia.pl/WYTYCZNE-PTL-KLRwP-PTK-r-nPTDL-PTD-PTNT-DIAGNOSTYKI-r-nI-LECZENIA-ZABURZEN-r-nLIPIDOWYCH-W-POLSCE-2021,166,45338,1,1.html

  • Global InfoBase W. The SuRF Report 2 Surveillance of chronic disease Risk Factors: Country-level data and comparable estimates The SuRF Report 2 CD-rom included The SuRF Report 2-Country-level data and comparable estimates.

  • Bentham J, Di Cesare M, Bilano V, et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017;390(10113):2627–42. https://doi.org/10.1016/S0140-6736(17)32129-3.

    Article 

    Google Scholar 

  • Lavie CJ, McAuley PA, Church TS, Milani RV, Blair SN. Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox. J Am Coll Cardiol. 2014;63(14):1345–54. https://doi.org/10.1016/J.JACC.2014.01.022.

    Article 
    PubMed 

    Google Scholar 

  • Alagiakrishnan K, Banach M, Ahmed A, Aronow WS. Complex relationship of obesity and obesity paradox in heart failure – higher risk of developing heart failure and better outcomes in established heart failure. Ann Med. 2016;48(8):603–13. https://doi.org/10.1080/07853890.2016.1197415.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Dobrowolski P, Prejbisz A, Kuryłowicz A, et al. Guidelines/Recommendations Metabolic Syndrome Metabolic syndrome-a new definition and management guidelines. Agnieszka Mastalerz-Migas. 2022;16:24. https://doi.org/10.5114/aoms/152921.

    Article 
    CAS 

    Google Scholar 

  • Osadnik K, Osadnik T, Gierlotka M, et al. Metabolic syndrome is associated with similar long-term prognosis in non-obese and obese patients. An analysis of 45 615 patients from the nationwide LIPIDOGRAM 2004–2015 cohort studies. Eur J Prev Cardiol. 2023. https://doi.org/10.1093/eurjpc/zwad101.

    Article 
    PubMed 

    Google Scholar 

  • Kaess BM, Jóźwiak J, Nelson CP, et al. The relation of rapid changes in obesity measures to lipid profile—insights from a nationwide metabolic health survey in 444 Polish cities. PLoS ONE. 2014. https://doi.org/10.1371/JOURNAL.PONE.0086837.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jóźwiak J, Kasperczyk S, Tomasik T, et al. Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies. Arch Med Sci. 2020. https://doi.org/10.5114/aoms.2020.96052.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Alberti KGMM, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–5. https://doi.org/10.1161/CIRCULATIONAHA.109.192644.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Rydén L, Grant PJ, Anker SD, et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD The Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J. 2013;34(39):3035–87. https://doi.org/10.1093/EURHEARTJ/EHT108.

    Article 
    PubMed 

    Google Scholar 

  • Balkau B, Charles MA. Comment on the provisional report from the WHO consultation. Diabet Med. 1999;16(5):442–3. https://doi.org/10.1046/j.1464-5491.1999.00059.x.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • De G, Ambrosioni E, Borch-Johnsen K, et al. Executive summary European guidelines on cardiovascular disease prevention in clinical practice Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of eight societies and by invited experts). Atherosclerosis. 2004;173:381–91. https://doi.org/10.1016/S0021-9150(03)00419-2.

    Article 

    Google Scholar 

  • Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289(19):2560–72. https://doi.org/10.1001/JAMA.289.19.2560.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Afzal S, Tybjærg-Hansen A, Jensen GB, Nordestgaard BG. Change in body mass index associated with lowest mortality in Denmark, 1976–2013. JAMA. 2016;315(18):1989–96. https://doi.org/10.1001/jama.2016.4666.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Romero-Corral A, Montori VM, Somers VK, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet. 2006;368(9536):666–78. https://doi.org/10.1016/S0140-6736(06)69251-9.

    Article 
    PubMed 

    Google Scholar 

  • Niedziela J, Hudzik B, Niedziela N, et al. The obesity paradox in acute coronary syndrome: a meta-analysis. Eur J Epidemiol. 2014;29(11):801–12. https://doi.org/10.1007/S10654-014-9961-9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gravina G, Ferrari F, Nebbiai G. The obesity paradox and diabetes. Eat Weight Disord. 2021;26(4):1057–68. https://doi.org/10.1007/S40519-020-01015-1.

    Article 
    PubMed 

    Google Scholar 

  • Gurevitz C, Assali A, Mohsan J, et al. The obesity paradox in patients with acute coronary syndromes over 2 decades—the ACSIS registry 2000–2018. Int J Cardiol. 2023;380:48–55. https://doi.org/10.1016/j.ijcard.2023.03.038.

    Article 
    PubMed 

    Google Scholar 

  • Khalangot M, Tronko M, Kravchenko V, Kulchinska J, Hu G. Body mass index and the risk of total and cardiovascular mortality among patients with type 2 diabetes: a large prospective study in Ukraine. Heart. 2009;95(6):454. https://doi.org/10.1136/hrt.2008.150524.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Horwich TB, Fonarow GC, Clark AL. Obesity and the obesity paradox in heart failure. Prog Cardiovasc Dis. 2018;61(2):151–6. https://doi.org/10.1016/J.PCAD.2018.05.005.

    Article 
    PubMed 

    Google Scholar 

  • Lee DH, Giovannucci EL. The obesity paradox in cancer: epidemiologic insights and perspectives. Curr Nutr Rep. 2019;8(3):175–81. https://doi.org/10.1007/S13668-019-00280-6.

    Article 
    PubMed 

    Google Scholar 

  • Shaw GB, Bosomworth NJ, Fcfp C. The downside of weight loss: realistic intervention in body-weight trajectory. Can Fam Physician. 2012;58(5):517.

    Google Scholar 

  • Prospective Studies Collaboration. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373(9669):1083–96. https://doi.org/10.1016/S0140-6736(09)60318-4.

    Article 
    PubMed Central 

    Google Scholar 

  • Marcks N, Aimo A, Januzzi JL, et al. Re-appraisal of the obesity paradox in heart failure: a meta-analysis of individual data. Clin Res Cardiol. 2021;110(8):1280–91. https://doi.org/10.1007/S00392-021-01822-1.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ali S, Garcia JM. Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options—a mini-review. Gerontology. 2014;60(4):294–305. https://doi.org/10.1159/000356760.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • McDonagh TA, Metra M, Adamo M, et al. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599–726. https://doi.org/10.1093/EURHEARTJ/EHAB368.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • O’Connor CM, Whellan DJ, Lee KL, et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009;301(14):1439–50. https://doi.org/10.1001/JAMA.2009.454.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Taylor RS, Walker S, Smart NA, et al. Impact of exercise rehabilitation on exercise capacity and quality-of-life in heart failure: individual participant meta-analysis. J Am Coll Cardiol. 2019;73(12):1430–43. https://doi.org/10.1016/J.JACC.2018.12.072.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Prausmüller S, Heitzinger G, Pavo N, et al. Malnutrition outweighs the effect of the obesity paradox. J Cachexia Sarcopenia Muscle. 2022;13(3):1477–86. https://doi.org/10.1002/jcsm.12980.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Harrington M, Gibson S, Cottrell RC. A review and meta-analysis of the effect of weight loss on all-cause mortality risk. Nutr Res Rev. 2009;22(1):93–108. https://doi.org/10.1017/S0954422409990035.

    Article 
    PubMed 

    Google Scholar 

  • Overvad TF, Rasmussen LH, Skjøth F, Overvad K, Lip GYH, Larsen TB. Body mass index and adverse events in patients with incident atrial fibrillation. Am J Med. 2013. https://doi.org/10.1016/J.AMJMED.2012.11.024.

    Article 
    PubMed 

    Google Scholar 

  • Springer J, Springer JI, Anker SD. Muscle wasting and sarcopenia in heart failure and beyond: update 2017. ESC Heart Fail. 2017;4(4):492–8. https://doi.org/10.1002/EHF2.12237.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Emami A, Saitoh M, Valentova M, et al. Comparison of sarcopenia and cachexia in men with chronic heart failure: results from the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF). Eur J Heart Fail. 2018;20(11):1580–7. https://doi.org/10.1002/EJHF.1304.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ryan DH, Yockey SR. Weight loss and improvement in comorbidity: differences at 5%, 10%, 15%, and over. Curr Obes Rep. 2017;6(2):187. https://doi.org/10.1007/S13679-017-0262-Y.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wadden TA. The look AHEAD study: a description of the lifestyle intervention and the evidence supporting it. Obesity (Silver Spring). 2006;14(5):737. https://doi.org/10.1038/OBY.2006.84.

    Article 
    PubMed 

    Google Scholar 

  • Sørensen TIA, Rissanen A, Korkeila M, Kaprio J. Intention to lose weight, weight changes, and 18-y mortality in overweight individuals without co-morbidities. PLoS Med. 2005;2(6):0510–20. https://doi.org/10.1371/JOURNAL.PMED.0020171.

    Article 

    Google Scholar 

  • Wilding JPH, Batterham RL, Davies M, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553–64. https://doi.org/10.1111/DOM.14725.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Huang S, Shi K, Ren Y, et al. Association of magnitude of weight loss and weight variability with mortality and major cardiovascular events among individuals with type 2 diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol. 2022;21(1):78. https://doi.org/10.1186/s12933-022-01503-x.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Orsi E, Solini A, Penno G, et al. Body mass index versus surrogate measures of central adiposity as independent predictors of mortality in type 2 diabetes. Cardiovasc Diabetol. 2022;21(1):266. https://doi.org/10.1186/s12933-022-01706-2.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Loeb LA, Ernster VL, Warner KE, Abbotts J, Laszlo J. Smoking and lung cancer: an overview. Cancer Res. 1984;44(12 Pt 1):5940–58.

    CAS 
    PubMed 

    Google Scholar 

  • Cornfield J, Haenszel W, Hammond EC, Lilienfeld AM, Shimkin MB, Wynder EL. Smoking and lung cancer: recent evidence and a discussion of some questions. Int J Epidemiol. 2009;38(5):1175–91. https://doi.org/10.1093/IJE/DYP289.

    Article 
    PubMed 

    Google Scholar 

  • Dare S, Mackay DF, Pell JP. Relationship between smoking and obesity: a cross-sectional study of 499,504 middle-aged adults in the UK general population. PLoS ONE. 2015. https://doi.org/10.1371/JOURNAL.PONE.0123579.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Watanabe T, Tsujino I, Konno S, et al. Association between smoking status and obesity in a nationwide survey of Japanese adults. PLoS ONE. 2016. https://doi.org/10.1371/JOURNAL.PONE.0148926.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Borrelli B, Mermelstein R. The role of weight concern and self-efficacy in smoking cessation and weight gain among smokers in a clinic-based cessation program. Addict Behav. 1998;23(5):609–22. https://doi.org/10.1016/S0306-4603(98)00014-8.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Veronese N, Li Y, Manson JE, Willett WC, Fontana L, Hu FB. Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: prospective cohort study. BMJ. 2016. https://doi.org/10.1136/BMJ.I5855.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sperrin M, Candlish J, Badrick E, Renehan A, Buchan I. Collider bias is only a partial explanation for the obesity paradox. Epidemiology. 2016;27(4):525. https://doi.org/10.1097/EDE.0000000000000493.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Banack HR, Stokes A. The ‘obesity paradox’ may not be a paradox at all. Int J Obes. 2017;41(8):1162–3. https://doi.org/10.1038/ijo.2017.99.

    Article 
    CAS 

    Google Scholar 

  • Schneider EB. Collider bias in economic history research. Explor Econ Hist. 2020;78:101356. https://doi.org/10.1016/j.eeh.2020.101356.

    Article 

    Google Scholar 

  • Ramsden CE, Zamora D, Majchrzak-Hong S, et al. Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968–73). BMJ. 2016;353:i1246. https://doi.org/10.1136/bmj.i1246.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Action to Control Cardiovascular Risk in Diabetes Study Group; Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358(24):2545–2559. https://doi.org/10.1056/NEJMoa0802743

  • Pavlov M, Nikolic-Heitzler V. Obesity paradox in acute myocardial infarction: is plasminogen activator inhibitor 1 the culprit? Med Hypotheses. 2023;176:111096. https://doi.org/10.1016/j.mehy.2023.111096.

    Article 
    CAS 

    Google Scholar 

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