Abstract Ameloblasts are specialized epithelial cells in the jaw that have an indispensable role in tooth enamel formation—amelogenesis1. Amelogenesis depends on multiple ameloblast-derived proteins that function as a scaffold for hydroxyapatite crystals. The loss of function of ameloblast-derived proteins results in a group of rare congenital disorders called amelogenesis imperfecta2. Defects in enamel formation are […]
Abstract The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by vaccination based on the ancestral (hereafter referred to as WT) strain would compromise the antibody response to Omicron-based boosters1,2,3,4,5. Vaccination strategies to counter immune imprinting are critically needed. Here we investigated the degree and dynamics […]
Abstract Necessary and sufficient opioids should be administered for safe and stable anesthesia. However, opioid sensitivity varies among individuals. We previously reported that sympathetic responses to nociceptive stimuli under propofol anesthesia could be predicted by measuring the minimum evoked current of the vascular stiffness value (MECK). However, this result has only been proven under propofol […]
RESEARCH HIGHLIGHT 22 November 2023 Sarah Crunkhorn Sarah Crunkhorn .readcube-buybox { display: none !important;} There is an urgent need for new therapeutic approaches for drug-resistant Pseudomonas aeruginosa (PA), a gram-negative pathogen that frequently causes severe infections, including pneumonia and sepsis. Now, writing in Cell, Simonis et al. identify human antibodies targeting the PA type III […]
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Abstract Amphibian skin harbors microorganisms that are associated with the fungal pathogen Batrachochytrium dendrobatidis (Bd), which causes chytridiomycosis, one of the most significant wildlife diseases known. This pathogen originated in Asia, where diverse Bd lineages exist; hence, native amphibian hosts have co-existed with Bd over long time periods. Determining the nuances of this co-existence is […]
The UK Government has committed £5million in seed funding to support a joint Imperial initiative to fight antimicrobial resistance. The Chancellor of the Exchequer has announced that £5million will be made available to the Fleming Centre – a partnership between Imperial College London and Imperial College Healthcare NHS Trust. The announcement was made in the […]
Abstract This study assessed the association between COVID-19 vaccines, SARS-CoV-2 infection and the risk of thrombocytopenia and venous thromboembolism (VTE). This self-controlled case series study used hospital records between 1st February 2021 and 28th February 2022 linked to the national immunisation registry and COVID-19 surveillance data in Malaysia. Conditional Poisson regression was used to estimate […]
Dublin, Nov. 22, 2023 (GLOBE NEWSWIRE) — The “TCR-Therapy – Pipeline Insight, 2023” drug pipelines has been added to ResearchAndMarkets.com’s offering. This report provides comprehensive insights about 30+ companies and 100+ pipeline drugs in TCR-Therapy pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment […]
Abstract Diagnosis of aneurysm and possibility of aneurysm rupture are crucial for avoiding brain hemorrhage. In this work, blood stream inside internal carotid arteries (ICAs) are simulated in diverse working conditions to disclose the importance of hemodynamic factors on the rupture of aneurysm. The main attention of this study is to investigate the role of […]