Abstract Persistent symptoms following the acute phase of COVID-19 present a major burden to both the affected and the wider community. We conducted a cohort study including over 856,840 first COVID-19 cases, 72,422 re-infections and more than 3.1 million first negative-test controls from primary care electronic health records from Spain and the UK (Sept 2020 […]
Our study at a large London tertiary hospital during the first wave of the UK epidemic found that 84.7% of patients with severe COVID-19 received antimicrobial therapy, despite only 13.3% developing a microbiologically confirmed bacterial or fungal infection. The majority of infections were hospital-acquired, secondary infections with Gram-negative organisms. In those who received immunosuppressive therapy […]
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Senescent cells in the brain contribute to age-related neurodegeneration. Analysis of SARS-CoV-2 infection in human brain organoids, animals and post-mortem brain samples from patients with COVID-19 reveals virus-induced senescence. Pharmacological senolytic treatment following SARS-CoV-2 infection improves COVID-19 neuropathology and could help to protect people from long COVID. This is a preview of subscription content, access […]
Newswise — LOS ANGELES (Nov. 17, 2023) — Investigators from the Barbra Streisand Women’s Heart Center in the Smidt Heart Institute at Cedars-Sinai have found that among a cohort of women with obstructive coronary artery disease treated at academic medical centers, racial and ethnic disparities did not impact their long-term outcomes. The findings were recently published in the Canadian Journal of […]
The first human clinical trial of a novel gene-editing technique known as base editing has shown promising results in maintaining healthy levels of cholesterol. In the trial by Verve Therapeutics, physicians injected patients with a Clustered Regularly Interspace Short Palindromic Repeats (CRISPR)-based gene editing therapy called VERVE-101, which inactivated the liver gene PCSK9 that typically […]
Abstract PM2.5, a key component of air pollution, significantly threatens public health. Cardiovascular disease is increasingly associated with air pollution, necessitating more research. This study used a meticulous two-sample Mendelian randomization (MR) approach to investigate the potential causal link between elevated PM2.5 levels and 25 types of cardiovascular diseases. Data sourced from the UK Biobank, […]
The study population The data were extracted from the SARS-CoV-2 infection surveillance system in South Kivu (DRC) during the 2020 pandemic. The population of South Kivu is approximately 4,800,000 people who live in a 64,492 km² area. The study considered the first thousand alert cases recorded between March 29 and November 29, 2020. An alert case […]
Practice patterns by type of operation In total, there were 18,216 appendiceal tumors in the study group, including 1,970 (11%) GCA, 6,219 (34%) mucinous adenocarcinoma, 5,603 (31%) NEN, and 4,424 (24%) non-mucinous adenocarcinoma tumors. A majority of all patients were treated with RHC (60%). Overall, RHC was most frequently performed in GCA (69%) and least […]
Health-related QoL (HRQOL) is the functional effect of an illness or disorder and its consequent therapy upon a patient, as perceived by the patient [17]. Though subjective, it is a crucial aspect in patient care and provides valuable insight into holistic management of health conditions. TS affects growth and development and its comorbidities have an […]