Monthly Archives: November 2023

Infographic: TB Is the World’s Second Deadliest Infectious Disease

Tuberculosis, or TB, was the world’s second deadliest infectious disease in 2022, following only after Covid-19. According to data from the World Health Organization, an estimated 1.13 million HIV-negative people died from TB last year. To put this into perspective, the officially reported death toll for Covid was 1.24 million in 2022, while total deaths […]

American Heart Association Scientific Sessions Feature Mass General Brigham Research and Advancements

Beginning November 11, Mass General Brigham experts will be sharing the latest advancements in cardiovascular science and clinical care at the American Heart Association’s 2023 Scientific Sessions. The studies highlighted below represent only a sample of the cutting-edge research that our investigators will present at the conference. Please contact Ryan Jaslow for more details about […]

FDA Panel Backs High-Risk Designation for Salvaged Blood Irradiators

There are not enough safety and efficacy data for the FDA to issue a low-risk Class II device classification for salvaged blood irradiators used to prevent metastasis during surgery, an advisory panel agreed on Tuesday. Members of the Radiological Devices Advisory Panel said that these devices should carry a high-risk Class III designation, meaning that […]

Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave

Abstract Identification of the risk factors and the high-risk groups which are most vulnerable is critical in COVID-19 disease management at a population level. Evaluating the efficacy of vaccination against infections is necessary to determine booster vaccination strategies for better protection in high-risk groups. In this study, we recruited 158 mRNA-vaccinated individuals during the Delta […]

Single-cell analysis identifies genes facilitating rhizobium infection in Lotus japonicus

Abstract Legume-rhizobium signaling during establishment of symbiotic nitrogen fixation restricts rhizobium colonization to specific cells. A limited number of root hair cells allow infection threads to form, and only a fraction of the epidermal infection threads progress to cortical layers to establish functional nodules. Here we use single-cell analysis to define the epidermal and cortical […]

Vital Signs: Missed Opportunities for Preventing Congenital

Discussion Lack of timely testing and adequate treatment during pregnancy contributed to 88% of congenital syphilis cases in 2022 and represent missed opportunities to prevent maternal syphilis-associated morbidity. Lack of timely testing and adequate treatment contributed to substantial proportions of cases in all geographic areas and in all racial and ethnic groups. Timely testing without […]

Exploring the impact of population ageing on the spread of emerging respiratory infections and the associated burden of mortality

Lanzieri G. The greying of the baby boomers. A century-long view of ageing in European populations. Technical report. 2011. Gavazzi G, Herrmann F, Krause KH. Aging and infectious diseases in the developing world. Clin Infect Dis. 2004;39(1):83–91. https://doi.org/10.1086/421559. Article  PubMed  Google Scholar  Preston SH, Stokes A. Sources of Population Aging in More and Less Developed […]

Associations between maternal metabolic conditions and neurodevelopmental conditions in offspring: the mediating effects of obstetric and neonatal complications

Obesity and overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed 21 Sep 2021. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843. PubMed  Google Scholar  Faraone […]