Abstract The first endothelin (ET)-1 receptor antagonist was approved for clinical use over 20 years ago, but to date this class of compounds has been limited to treating pulmonary arterial hypertension, a rare disease. Translational research over the last 5 years has reignited interest in the ET system as a therapeutic target across the spectrum […]
Monthly Archives: November 2023
Preclinical data indicate that narazaciclib shows monotherapy and combination anti-tumor activity in ibrutinib-sensitive and resistant cells and xenograft models NEWTOWN, Pa., Nov. 02, 2023 (GLOBE NEWSWIRE) — Onconova Therapeutics, Inc. (NASDAQ: ONTX), (“Onconova” or “the Company”), a clinical-stage biopharmaceutical company focused on discovering and developing novel products for patients with cancer, today announced that Onconova […]
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Specialty
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November 02, 2023 5 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . <button type="button" class="btn btn-primary" data-loading-text="Loading ” data-action=”subscribe”> Subscribe Added to email alerts We were unable to process your request. […]
Cancer and neoplasms
Karyopharm Reports Third Quarter 2023 Financial Results and Highlights Recent Company Progress
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Karyopharm Reports Third Quarter 2023 Financial Results and Highlights Recent Company Progress – Achieved Third Quarter 2023 Total Revenue of $36.0 Million and U.S. XPOVIO® (selinexor) Net Product Revenue of $30.2 Million – – Maintains Full Year 2023 Total Revenue Guidance of $145 Million to $160 Million, Including U.S. XPOVIO Net Product Revenue Guidance of […]
Blood
Apple Watch 10 to measure blood pressure, blood sugar measurement was already planned for the first Apple Watch
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But this doesn’t mean Apple has no exciting new health features planned for the near future. After the heart rate sensor of the first Apple Watch, Apple has been able to add a SpO2 sensor, an electrocardiogram (ECG) and a skin temperature sensor over the years. Next year, the smartwatch’s health features will be expanded […]
Infection
Interpretable machine learning-based decision support for prediction of antibiotic resistance for complicated urinary tract infections
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Abstract Urinary tract infections are one of the most common bacterial infections worldwide; however, increasing antimicrobial resistance in bacterial pathogens is making it challenging for clinicians to correctly prescribe patients appropriate antibiotics. In this study, we present four interpretable machine learning-based decision support algorithms for predicting antimicrobial resistance. Using electronic health record data from a […]
Infection
Markers of intestinal mucositis to predict blood stream infections at the onset of fever during treatment for childhood acute leukemia
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Abstract Despite chemotherapy-induced intestinal mucositis being a main risk factor for blood stream infections (BSIs), no studies have investigated mucositis severity to predict BSI at fever onset during acute leukemia treatment. This study prospectively evaluated intestinal mucositis severity in 85 children with acute leukemia, representing 242 febrile episodes (122 with concurrent neutropenia) by measuring plasma […]