Monthly Archives: November 2023

Association between levels of receptor binding domain antibodies of SARS-CoV-2, receipt of booster and risk of breakthrough infections: LA pandemic surveillance cohort study

Abstract Prevention of COVID-19 with vaccine requires multiple doses and updated boosters to maintain protection; however currently there are no tests that can measure immunity and guide clinical decisions about timing of booster doses. This study examined the association between the risk of COVID-19 breakthrough infections and receptor binding domain (RBD) antibody levels and receipt […]

COVID 19 infection clinical features in pediatric patients in Southwestern Iran: a cross-sectional, multi-center study

This study assessed the presence of SARS-CoV-2 infection rate using Taq man real-time PCR assay and the epidemiological and clinical data of them, in the southwest of Iran during 17 months of post-pandemic period. The mean age of infected patients was 5.71 years that is consistent with Dong et al.’s study [8]. Global data shows mixed […]

Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis

Abstract Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of LC patients represents a source of potential LC biomarkers. We compared expression of > 60,000 genes in whole blood specimens taken from […]

Impacts of COVID-19 pandemic through decomposition of life expectancy according to leading causes and place of death in Czechia

Abstract While the direct effects of the pandemic are well documented, less is known about the indirect ones, including changes in healthcare provision or human behavior. This paper aims to study the impact of indirect consequences on mortality, focusing on two leading causes (cardiovascular diseases, COVID-19) and places of death in Czechia, during the COVID-19 […]

Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infection

Abstract Clinical immunity against Plasmodium falciparum infection develops in residents of malaria endemic regions, manifesting in reduced clinical symptoms during infection and in protection against severe disease but the mechanisms are not fully understood. Here, we compare the cellular and humoral immune response of clinically immune (0-1 episode over 18 months) and susceptible (at least […]

Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis

Abstract Current therapies for myeloproliferative neoplasms (MPNs) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem/progenitor cells (HSPCs). TAMARIN Phase-II, multicenter, single-arm clinical trial assessed tamoxifen’s safety and activity in patients with stable MPNs, no prior thrombotic events and mutated JAK2V617F, CALRins5 or CALRdel52 […]

An explainable machine learning-based phenomapping strategy for adaptive predictive enrichment in randomized clinical trials

Abstract Randomized clinical trials (RCT) represent the cornerstone of evidence-based medicine but are resource-intensive. We propose and evaluate a machine learning (ML) strategy of adaptive predictive enrichment through computational trial phenomaps to optimize RCT enrollment. In simulated group sequential analyses of two large cardiovascular outcomes RCTs of (1) a therapeutic drug (pioglitazone versus placebo; Insulin […]

Researchers probe Kawasaki disease causes as infections plunge amid COVID outbreak

Kawasaki disease, of yet-unknown causes, has seen a sharp decrease since the spread of the novel coronavirus. (Mainichi) TOKYO — Since the coronavirus pandemic began, the number of young children affected by Kawasaki disease in Japan has sharply declined, according to a nonprofit agency that studies the mysterious illness. The disease, discovered by Tomisaku Kawasaki […]

What we know so far about surging cases of respiratory illnesses in China

PARIS – Cases of respiratory illnesses have been surging in northern China, particularly among children, sparking speculation online of a new pandemic threat four years after Covid-19 first emerged in the country. However, the Chinese health authorities have said the rising infections are a mix of already known viruses and are linked to the country’s […]