Cardiovascular
Myocardial bioenergetic profiling in patients with stable ischemic heart disease
09
Aug
Aug
Patients with chronic ischemic heart disease — an important cause of heart failure — show altered myocardial bioenergetics with metabolomic and transcriptomic changes that seem to occur at a global, rather than regional, level in human hearts.
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References
-
Ziaeian, B. & Fonarow, G. C. Epidemiology and aetiology of heart failure. Nat. Rev. Cardiol. 13, 368–378 (2016). This review article discusses the global burden of heart failure and the common predisposing diseases.
Google Scholar
-
Wilcox, J. E. “Targeting the heart” in heart failure: myocardial recovery in heart failure with reduced ejection fraction. JACC Heart Fail. 3, 661–669 (2015). This review discusses the need to identify the key myocardial molecular abnormalities related to progressive cardiac dysfunction.
Google Scholar
-
Chouchani, E. T. et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 515, 431–435 (2014). This research paper highlights the accumulation of succinate as a universal metabolic signature of ischemia in a range of tissues.
Google Scholar
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This is a summary of: Jones, R. E. et al. Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00312-z (2023).
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Myocardial bioenergetic profiling in patients with stable ischemic heart disease.
Nat Cardiovasc Res (2023). https://doi.org/10.1038/s44161-023-00318-7
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Published: 09 August 2023
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DOI: https://doi.org/10.1038/s44161-023-00318-7
