Racial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States

1. Vos, T. et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396, 1204–1222 (2020).

   Article 

   Google Scholar 

2. Brunekreef, B. et al. Mortality and morbidity effects of long-term exposure to low-level PM2.5, BC, NO2, and O3: an analysis of European cohorts in the ELAPSE Project. HEI Report Series (2021).

3. Crouse, D. L. et al. Risk of nonaccidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fine particulate matter: a Canadian national-level cohort study. Environ. Health Perspect. 120, 708–714 (2012).

   Article 
   PubMed 
   PubMed Central 

   Google Scholar 

4. Brauer, M. et al. Mortality–Air Pollution Associations in Low-Exposure Environments (MAPLE): phase 2. HEI Report Series (2022).

5. Dominici, F. et al. Assessing adverse health effects of long-term exposure to low levels of ambient air pollution: implementation of causal inference methods. HEI Report Series (2022).

6. Di, Q. et al. An ensemble-based model of PM2.5 concentration across the contiguous United States with high spatiotemporal resolution. Environ. Int. 130, 104909 (2019).

   Article 
   CAS 
   PubMed 
   PubMed Central 

   Google Scholar 

7. Hubbell, B. J., Crume, R. V., Evarts, D. M. & Cohen, J. M. Policy monitor: regulation and progress under the 1990 Clean Air Act amendments. Rev. Environ. Econ. Policy 4, 122–138 (2010).

   Article 

   Google Scholar 

8. Fann, N., Coffman, E., Timin, B. & Kelly, J. T. The estimated change in the level and distribution of PM2.5-attributable health impacts in the United States: 2005–2014. Environ. Res. 167, 506–514 (2018).

   Article 
   CAS 
   PubMed 
   PubMed Central 

   Google Scholar 

9. Diderichsen, F., Hallqvist, J. & Whitehead, M. Differential vulnerability and susceptibility: how to make use of recent development in our understanding of mediation and interaction to tackle health inequalities. Int J. Epidemiol. 48, 268–274 (2019).

   Article 
   PubMed 

   Google Scholar 

10. US Global Change Research Program. The Impacts of Climate Change on Human Health in the United States: A Scientific Assessment (USGCRP, 2016).

11. Liu, J. et al. Disparities in air pollution exposure in the United States by race/ethnicity and income, 1990–2010. Environ. Health Perspect. 129, 127005 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

12. Tessum, C. W. et al. PM2.5 polluters disproportionately and systemically affect people of color in the United States. Sci. Adv. 7, eabf4491 (2021).

    Article 
    PubMed 

    Google Scholar 

13. Jbaily, A. et al. Air pollution exposure disparities across US population and income groups. Nature 601, 228–233 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

14. Hajat, A., Hsia, C. & O’Neill, M. S. Socioeconomic disparities and air pollution exposure: a global review. Curr. Environ. Health Rep. 2, 440–450 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

15. Colmer, J., Hardman, I., Shimshack, J. & Voorheis, J. Disparities in PM2.5 air pollution in the United States. Science 369, 575–578 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

16. Kravitz-Wirtz, N., Crowder, K., Hajat, A. & Sass, V. The long-term dynamics of racial/ethnic inequality in neighborhood air pollution exposure, 1990-2009. Du Bois Rev. 13, 237–259 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

17. Wright, W. J. As above, so below: anti-Black violence as environmental racism. Antipode 53, 791–809 (2021).

    Article 

    Google Scholar 

18. Gottlieb, R. Forcing the Spring: the Transformation of the American Environmental Movement (Island Press, 2005).

19. Woo, B. et al. Residential segregation and racial/ethnic disparities in ambient air pollution. Race Soc. Probl. 11, 60–67 (2019).

    Article 
    PubMed 

    Google Scholar 

20. Mascarenhas, M., Grattet, R. & Mege, K. Toxic waste and race in twenty-first century America: neighborhood poverty and racial composition in the siting of hazardous waste facilities. Environ. Soc. 12, 108–126 (2021).

    Article 

    Google Scholar 

21. Rigolon, A., Yañez, E., Aboelata, M. J. & Bennett, R. ‘A park is not just a park’: toward counter-narratives to advance equitable green space policy in the United States. Cities 128, 103792 (2022).

    Article 

    Google Scholar 

22. Rigolon, A., Browning, M. H., McAnirlin, O. & Yoon, H. Green space and health equity: a systematic review on the potential of green space to reduce health disparities. Int J. Environ. Res. Public Health 18, 2563 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

23. Di, Q. et al. Air pollution and mortality in the Medicare population. N. Engl. J. Med. 376, 2513–2522 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

24. Spiller, E., Proville, J., Roy, A. & Muller, N. Z. Mortality risk from PM2.5: a comparison of modeling approaches to identify disparities across racial/ethnic groups in policy outcomes. Environ. Health Perspect. 129, 127004 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

25. Krieger, N. Discrimination and health inequities. Int J. Health Serv. 44, 643–710 (2014).

    Article 
    PubMed 

    Google Scholar 

26. Bailey, Z. D. et al. Structural racism and health inequities in the USA: evidence and interventions. Lancet 389, 1453–1463 (2017).

    Article 
    PubMed 

    Google Scholar 

27. Williams, D. R. Stress and the mental health of populations of color: advancing our understanding of race-related stressors. J. Health Soc. Behav. 59, 466–485 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

28. Zang, E. & Kim, N. Intergenerational upward mobility and racial differences in mortality among young adults: evidence from county-level analyses. Health Place 70, 102628 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

29. Seltenrich, N. The one-two-three punch: exposure, susceptibility, and disease burden among U.S. populations of color. Environ. Health Perspect. 130, 034001 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

30. Van Horne, Y. O. et al. An applied environmental justice framework for exposure science. J. Expo. Sci. Environ. Epidemiol. https://doi.org/10.1038/s41370-022-00422-z (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

31. Renzi, M. et al. Long-term PM10 exposure and cause-specific mortality in the Latium region (Italy): a difference-in-differences approach. Environ. Health Perspect. 127, 067004 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

32. Götschi, T. et al. Elemental composition and reflectance of ambient fine particles at 21 European locations. Atmos. Environ. 39, 5947–5958 (2005).

    Article 

    Google Scholar 

33. Atkinson, R. W., Mills, I. C., Walton, H. A. & Anderson, H. R. Fine particle components and health—a systematic review and meta-analysis of epidemiological time series studies of daily mortality and hospital admissions. J. Expo. Sci. Environ. Epidemiol. 25, 208–214 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar 

34. Kapetanios, G., Pesaran, M. H. & Yamagata, T. Panels with non-stationary multifactor error structures. J. Econ. 160, 326–348 (2011).

    Article 

    Google Scholar 

35. Cartographic Boundary Files. United States Census Bureau https://www.census.gov/geographies/mapping-files/time-series/geo/cartographic-boundary.html (2019).

36. U.S. County Population Data – 1969–2020. The SEER Program https://seer.cancer.gov/popdata/ (2022).

37. Management, O. O. & Budget Revisions to the standards for the classification of federal data on race and ethnicity. Fed. Regist. 62, 58782–58790 (1997).

    Google Scholar 

38. Khatana, S. A. M., Werner, R. M. & Groeneveld, P. W. Association of extreme heat and cardiovascular mortality in the United States: a county-level longitudinal analysis from 2008 to 2017. Circulation 146, 249–261 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

39. Turner, M. C. et al. Long-term ozone exposure and mortality in a large prospective study. Am. J. Respir. Crit. Care Med 193, 1134–1142 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

40. Pope, C. A. 3rd et al. Relationships between fine particulate air pollution, cardiometabolic disorders, and cardiovascular mortality. Circ. Res. 116, 108–115 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar 

41. Di, Q. et al. Daily and annual PM2.5 concentrations for the contiguous United States, 1-km grids, v1 (2000–2016). NASA Socioeconomic Data and Applications Center. (NASA, Accessed 16 August 2022); https://doi.org/10.7927/0rvr-4538

42. Wei, Y. et al. Causal effects of air pollution on mortality rate in Massachusetts. Am. J. Epidemiol. 189, 1316–1323 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

43. Di, Q. et al. Assessing NO2 concentration and model uncertainty with high spatiotemporal resolution across the contiguous United States. Environ. Sci. Technol. 54, 1372–1384 (2019).

    Article 

    Google Scholar 

44. Di, Q. et al. Daily and annual NO2 concentrations for the contiguous United States, 1-km grids, v1 (2000–2016). NASA Socioeconomic Data and Applications Center. (NASA, Accessed 16 August 2022); https://doi.org/10.7927/f8eh-5864

45. Requia, W. J. et al. An ensemble learning approach for estimating high spatiotemporal resolution of ground-level ozone in the contiguous U.S. Environ. Sci. Technol. 54, 11037–11047 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

46. Requia, W. J. et al. Daily 8-hour maximum and annual O3 concentrations for the contiguous United States, 1-km grids, v1 (2000–2016). NASA Socioeconomic Data and Applications Center. (NASA, Accessed 16 August 2022); https://doi.org/10.7927/a4mb-4t86

47. PRISM Climate Group. PRISM Climate Data Recent Years (Jan 1981–Jan 2022) (2016).

48. Bai, J. Panel data models with interactive fixed effects. Econometrica 77, 1229–1279 (2009).

    Article 

    Google Scholar 

49. Goodman-Bacon, A. Difference-in-differences with variation in treatment timing. J. Econ. 225, 254–277 (2021).

    Article 

    Google Scholar 

50. Liu, L., Wang, Y. & Xu, Y. A practical guide to counterfactual estimators for causal inference with time-series cross-sectional data. Am. J. Pol. Sci. https://doi.org/10.1111/ajps.12723 (2022).

    Article 

    Google Scholar 

51. Xu, Y. Generalized synthetic control method: causal inference with interactive fixed effects models. Polit. Anal. 25, 57–76 (2017).

    Article 

    Google Scholar 

52. Bai, J. & Ng, S. Determining the number of factors in approximate factor models. Econometrica 70, 191–221 (2002).

    Article 

    Google Scholar 

53. Bada, O. & Liebl, D. phtt: panel data analysis with heterogeneous time trends in R. J. Stat. Softw. 59, 1–33 (2014).

    Article 

    Google Scholar 

54. NCHS Urban-Rural Classification Scheme for Counties. National Center for Health Statistics https://www.cdc.gov/nchs/data_access/urban_rural.htm (2017).

55. Chen, K. et al. Triggering of myocardial infarction by heat exposure is modified by medication intake. Nat. Cardiovasc Res 1, 727–731 (2022).

    Article 

    Google Scholar 

56. Benshaul-Tolonen, A. Local industrial shocks and infant mortality. Econ. J. 129, 1561–1592 (2019).

    Article 

    Google Scholar 

57. Ma, Y. et al. CHENlab-Yale/PM2.5_CVD_mortality_US: first release of the repository for PM2.5_CVD_mortality_US project. Zenodo https://doi.org/10.5281/zenodo.8121894 (2023).

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