Multiple refractory intracellular pathogen infections in a human immunodeficiency virus-negative patient with anti-interferon-γ autoantibodies: a case report

  • Döffinger R, Helbert MR, Barcenas-Morales G, Yang K, Dupuis S, Ceron-Gutierrez L, Espitia-Pinzon C, Barnes N, Bothamley G, Casanova JL, Longhurst HJ, Kumararatne DS. Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity. Clin Infect Dis. 2004;38(1):e10–4.

    Article 
    PubMed 

    Google Scholar 

  • Browne SK, Burbelo PD, Chetchotisakd P, Suputtamongkol Y, Kiertiburanakul S, Shaw PA, Kirk JL, Jutivorakool K, Zaman R, Ding L, Hsu AP, Patel SY, Olivier KN, Lulitanond V, Mootsikapun P, Anunnatsiri S, Angkasekwinai N, Sathapatayavongs B, Hsueh PR, Shieh CC, Brown MR, Thongnoppakhun W, Claypool R, Sampaio EP, Thepthai C, Waywa D, Dacombe C, Reizes Y, Zelazny AM, Saleeb P, Rosen LB, Mo A, Iadarola M, Holland SM. Adult-onset immunodeficiency in Thailand and Taiwan. N Engl J Med. 2012;367(8):725–34.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Xie YL, Rosen LB, Sereti I, Barber DL, Chen RY, Hsu DC, Qasba SS, Zerbe CS, Holland SM, Browne SK. Severe paradoxical reaction during treatment of disseminated tuberculosis in a patient with neutralizing anti-IFNγ autoantibodies. Clin Infect Dis. 2016;62(6):770–3.

    Article 
    PubMed 

    Google Scholar 

  • Wipasa J, Chaiwarith R, Chawansuntati K, Praparattanapan J, Rattanathammethee K, Supparatpinyo K. Characterization of anti-interferon-γ antibodies in HIV-negative immunodeficient patients infected with unusual intracellular microorganisms. Exp Biol Med (Maywood). 2018;243(7):621–6.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Liang X, Si L, Li Y, Zhang J, Deng J, Bai J, Li M, He Z. Talaromyces marneffei infection relapse presenting as osteolytic destruction followed by suspected nontuberculous mycobacterium infection during 6 years of follow-up: a case update. Int J Infect Dis. 2020;93:208–10.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Pruetpongpun N, Khawcharoenporn T, Damronglerd P, Suthiwartnarueput W, Apisarnthanarak A, Rujanavej S, Suwantarat N. Disseminated Talaromyces marneffei and Mycobacterium abscessus in a patient with anti-interferon-γ autoantibodies. Open Forum Infect Dis. 2016;3(2):ofw093.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Su SS, Zhang SN, Ye JR, Xu LN, Lin PC, Xu HY, Wu Q, Li YP. Disseminated Talaromyces marneffei and Mycobacterium avium infection accompanied Sweet’s syndrome in a patient with anti-interferon-γ autoantibodies: A case report. Infect Drug Resist. 2019;12:3189–95.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Roerden M, Döffinger R, Barcenas-Morales G, Forchhammer S, Döbele S, Berg CP. Simultaneous disseminated infections with intracellular pathogens: an intriguing case report of adult-onset immunodeficiency with anti-interferon-gamma autoantibodies. BMC Infect Dis. 2020;20(1):828.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jin W, Liu J, Chen K, Shen L, Zhou Y, Wang L. Coinfection by Talaromyces marneffei and Mycobacterium abscessus in a human immunodeficiency virus-negative patient with anti-interferon-γ autoantibody: a case report. J Int Med Res. 2021;49(1):300060520976471.

    Article 
    PubMed 

    Google Scholar 

  • Qiu Y, Pan M, Yang Z, Zeng W, Zhang H, Li Z, Zhang J. Talaromyces marneffei and Mycobacterium tuberculosis co-infection in a patient with high titer anti-interferon-γ autoantibodies: a case report. BMC Infect Dis. 2022;22(1):98.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tang BS, Chan JF, Chen M, Tsang OT, Mok MY, Lai RW, Lee R, Que TL, Tse H, Li IW, To KK, Cheng VC, Chan EY, Zheng B, Yuen KY. Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon. Clin Vaccine Immunol. 2010;17(7):1132–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chan JF, Trendell-Smith NJ, Chan JC, Hung IF, Tang BS, Cheng VC, Yeung CK, Yuen KY. Reactive and infective dermatoses associated with adult-onset immunodeficiency due to anti-interferon-gamma autoantibody: sweet’s syndrome and beyond. Dermatology. 2013;226(2):157–66.

    Article 
    PubMed 

    Google Scholar 

  • Kampitak T, Suwanpimolkul G, Browne S, Suankratay C. Anti-interferon-γ autoantibody and opportunistic infections: case series and review of the literature. Infection. 2011;39(1):65–71.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Qiu Y, Huang J, Li Y, Zeng W, Pan M, Cen J, Zhang H, Sun X, Qu D, Zhang J. Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients. Sci Rep. 2021;11(1):16177.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen YC, Weng SW, Ding JY, Lee CH, Ku CL, Huang WC, You HL, Huang WT. Clinicopathological manifestations and immune phenotypes in adult-onset immunodeficiency with anti-interferon-γ autoantibodies. J Clin Immunol. 2022;42(3):672–83.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Shih HP, Ding JY, Yeh CF, Chi CY, Ku CL. Anti-interferon-γ autoantibody-associated immunodeficiency. Curr Opin Immunol. 2021;72:206–14.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Chi CY, Chu CC, Liu JP, Lin CH, Ho MW, Lo WJ, Lin PC, Chen HJ, Chou CH, Feng JY, Fung CP, Sher YP, Li CY, Wang JH, Ku CL. Anti-IFN-γ autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection. Blood. 2013;121(8):1357–66.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ku CL, Lin CH, Chang SW, Chu CC, Chan JF, Kong XF, Lee CH, Rosen EA, Ding JY, Lee WI, Bustamante J, Witte T, Shih HP, Kuo CY, Chetchotisakd P, Kiertiburanakul S, Suputtamongkol Y, Yuen KY, Casanova JL, Holland SM, Doffinger R, Browne SK, Chi CY. Anti-IFN-γ autoantibodies are strongly associated with HLA-DR*15:02/16:02 and HLA-DQ*05:01/05:02 across Southeast Asia. J Allergy Clin Immunol. 2016;137(3):945-8.e8.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Li D, Liang H, Zhu Y, Chang Q, Pan P, Zhang Y. Clinical characteristics, laboratory findings, and prognosis in patients with Talaromyces marneffei infection across various immune statuses. Front Med (Lausanne). 2022;9: 841674.

    Article 
    PubMed 

    Google Scholar 

  • Pagliano P, Arslan F, Ascione T. Epidemiology and treatment of the commonest form of listeriosis: meningitis and bacteraemia. Infez Med. 2017;25(3):210–6.

    PubMed 

    Google Scholar 

  • Schlech WF. Epidemiology and clinical manifestations of Listeria monocytogenes infection. Microbiol Spectr. 2019;7(3).

  • Browne SK, Zaman R, Sampaio EP, Jutivorakool K, Rosen LB, Ding L, Pancholi MJ, Yang LM, Priel DL, Uzel G, Freeman AF, Hayes CE, Baxter R, Cohen SH, Holland SM. Anti-CD20 (rituximab) therapy for anti-IFN-γ autoantibody-associated nontuberculous mycobacterial infection. Blood. 2012;119(17):3933–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Czaja CA, Merkel PA, Chan ED, Lenz LL, Wolf ML, Alam R, Frankel SK, Fischer A, Gogate S, Perez-Velez CM, Knight V. Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-γ autoantibody. Clin Infect Dis. 2014;58(6):e115–8.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Koizumi Y, Sakagami T, Nishiyama N, Hirai J, Hayashi Y, Asai N, Yamagishi Y, Kato H, Hagihara M, Sakanashi D, Suematsu H, Ogawa K, Mikamo H. Rituximab restores IFN-γ-STAT1 function and ameliorates disseminated Mycobacterium avium infection in a patient with anti-interferon-γ autoantibody. J Clin Immunol. 2017;37(7):644–9.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sun X, Shen B, Yu H, Wu W, Sheng R, Fang Y, Guo R. Therapeutic potential of demethylzeylasteral, a triterpenoid of the genus Tripterygium wilfordii. Fitoterapia. 2022;13: 105333.

    Article 

    Google Scholar 

  • Chen M, Zhang P, Li L, Yu Z, Liu N, Wang L. Efficacy and safety of glycosides of Tripterygium wilfordii combined with renin-angiotensin system in the treatment of IgA nephropathy: A systematic review and meta-analysis. Emerg Med Int. 2022;2022:5314105.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

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