Key Points Question What is the prevalence and tumor spectrum of CDKN2A-related melanoma-astrocytoma syndrome? Findings In this cohort study of 640 292 individuals in 2 population genomic databases, melanoma-astrocytoma syndrome prevalence ranged from 1 in 170 503 to 1 in 39 149, and patients had a diverse spectrum of neural and nonneural tumors. Multiple patients had clinical diagnoses […]
Owen Dyer Montreal Recent testing has left little doubt that a new variant of the pandemic coronavirus is gaining ground across the world. The spike mutations of the EG.5 variant—dubbed “eris”—improve its immune escape abilities, experts have said, and probably account for recent modest increases in hospital admissions in Japan, New Zealand, South Korea, the […]
Abstract Disruption of the lung endothelial–epithelial cell barrier following respiratory virus infection causes cell and fluid accumulation in the air spaces and compromises vital gas exchange function1. Endothelial dysfunction can exacerbate tissue damage2,3, yet it is unclear whether the lung endothelium promotes host resistance against viral pathogens. Here we show that the environmental sensor aryl […]
Findings from a new large-scale clinical trial of Novo Nordisk‘s weight-loss drug Wegovy suggest that it may reduce the risk of serious cardiovascular events by 20%. Advisory Board‘s Regina Lohr and Gabriela Marmolejos share their three biggest takeaways from the trial and explain how these findings could impact chronic disease prevention. Wegovy may reduce the risk […]
One of the biggest culprits of serious viral illness in seniors will soon be rivaled by a powerful new vaccine, according to infectious disease authorities. The vaccine, which protects against respiratory syncytial virus (RSV), could be a game changer in preventing hospitalizations and deaths in people above 60. The Food and Drug Administration approved two vaccines, pharmaceutical company GSK’s Arexvy and Pfizer’s […]
In the ICU, we use blood—sometimes, by the gallon. A patient with, say, a gushing stomach ulcer might need transfusion after transfusion to keep the heart beating until the hemorrhage stops. Such blood products are not prescribed by physicians like me in “whole” form, but rather in parts that are separated after collection before being […]
Experts have warned that there is no safe threshold for drinking alcohol in terms of health risks. Kicking back with a drink amid the warm summer heat is a common experience for most Europeans but many remain unaware of the risks associated with consuming alcohol. ADVERTISEMENT Estimated to be a causal factor for more than […]
Abstract Segmental femoral bone defects are a severe challenge for orthopedic trauma surgeons. The objective of this study was to compare the efficacy of the shortening/re-lengthening and nailing (SRN) technique with the traditional bone transport (BT) technique in treating patients with such defects. A retrospective study was conducted involving 46 patients with segmental femoral bone […]
MIDLAND, Texas (KOSA) – A device the size of a grain of rice may be the difference between finding your lost pet or not. That device is a microchip and today is national Check the Chip Day. The day comes amid the death of Luna, a Midland dog who was euthanized before her owner could […]
LEHI, Utah — A 12-year-old Lehi girl is home after spending nearly two months in the hospital fighting a deadly type of bacteria that is resistant to several antibiotics. Tom Parkin lights up when describing his 12-year-old daughter, Diana. “Diana is a wonderful person,” he said, “very smart, very kind.” Parkin explained how Diana was […]