Category Archives: Cancer and neoplasms

Shattuck Labs to Present Topline Data from Phase 1 A/B Clinical Trial of SL-172154 in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and Higher-Risk Myelodysplastic Syndromes (HR-MDS) Patients

Shattuck Labs to Present Topline Data from Phase 1 A/B Clinical Trial of SL-172154 in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and Higher-Risk Myelodysplastic Syndromes (HR-MDS) Patients

HotSpot Therapeutics to Introduce First-in-Class MALT1 Scaffolding Inhibitor at 65th ASH Annual Meeting

Oral presentation will showcase distinct preclinical profile for potent, selective MALT1 scaffolding inhibitor that is highly differentiated from MALT1 protease inhibitors BOSTON, Nov. 2, 2023 /PRNewswire/ — HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of oral, small molecule allosteric therapies targeting regulatory sites on proteins referred to as “natural hotspots,” today […]

Influence of healthy lifestyle habits on chronic disorders

In a recent editorial published in Nutrients, researchers described the health benefits of regular exercise, a healthy diet, and adequate sleep. Study: Effects of Healthy Lifestyles on Chronic Diseases: Diet, Sleep and Exercise. Image Credit: Nok Lek Travel Lifestyle/Shutterstock.com Background The most impactful and controllable element influencing overall health and disease resilience is lifestyle. Chronic illness cases […]

Frailty, illness perception in lung cancer patients

1Wuxi School of Medicine, Jiangnan University, Wuxi, People’s Republic of China; 2Department of Cardiothoracic Surgery, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 3Department of Radiology, Huadong Sanatorium, Wuxi, People’s Republic of China Correspondence: Lei Jiang, Department of Radiology, Huadong Sanatorium, Wuxi, People’s Republic of China, Tel +86 13921272670, Email [email protected] Background: Lung […]

Onconova Therapeutics’ ASH Poster To Focus on Narazaciclib in MCL

Preclinical data indicate that narazaciclib shows monotherapy and combination anti-tumor activity in ibrutinib-sensitive and resistant cells and xenograft models NEWTOWN, Pa., Nov. 02, 2023 (GLOBE NEWSWIRE) — Onconova Therapeutics, Inc. (NASDAQ: ONTX), (“Onconova” or “the Company”), a clinical-stage biopharmaceutical company focused on discovering and developing novel products for patients with cancer, today announced that Onconova […]

Higher MDMX expression was associated with hypomethylating agent resistance and inferior survival in MDS patients, inferring it a potential therapeutic target

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The efficacy and safety assessment of oncolytic virotherapies in the treatment of advanced melanoma: a systematic review and meta-analysis

Galluzzi L, Humeau J, Buqué A, Zitvogel L, Kroemer G. Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors. Nat Rev Clin Oncol. 2020;17:725–41. https://doi.org/10.1038/s41571-020-0413-z. Article  PubMed  Google Scholar  Carlino MS, Larkin J, Long GV. Immune checkpoint inhibitors in melanoma. The Lancet. 2021;398:1002–14. https://doi.org/10.1016/S0140-6736(21)01206-X. Article  CAS  Google Scholar  Bagchi S, Yuan R, Engleman EG. […]

Human papillomavirus infections among women with cervical lesions and cervical cancer in Yueyang, China: a cross-sectional study of 3674 women from 2019 to 2022

HPV distribution characteristics in patients with cervical lesions Of the 3674 patients with cervical lesions, 2744 were positive for HPV, giving a prevalence of 74.69% (95% CI 73.28–76.09%). The prevalence of HPV in CIN I, CIN II, CIN III, and ICC groups were 66.65% (1273/1910, 95% CI 64.53–68.77%), 80.78% (580/718, 95% CI 77.89–83.67%), 83.88% (483/576, […]

2023-11-02 | NDAQ:RIGL | Press Release

— Growing body of data on REZLIDHIA® (olutasidenib) in mIDH1 relapsed or refractory (R/R) acute myeloid leukemia (AML) patients — — New data on olutasidenib in patients with mIDH1 myelodysplastic syndromes/neoplasms (MDS) — SOUTH SAN FRANCISCO, Calif., Nov. 2, 2023 /PRNewswire/ — Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced the upcoming presentation of four posters […]

Karyopharm Reports Third Quarter 2023 Financial Results and Highlights Recent Company Progress

Karyopharm Reports Third Quarter 2023 Financial Results and Highlights Recent Company Progress – Achieved Third Quarter 2023 Total Revenue of $36.0 Million and U.S. XPOVIO® (selinexor) Net Product Revenue of $30.2 Million – –  Maintains Full Year 2023 Total Revenue Guidance of $145 Million to $160 Million, Including U.S. XPOVIO Net Product Revenue Guidance of […]