Category Archives: Cancer and neoplasms

Abstract Upfront autologous stem cell transplant (ASCT) is the standard of care for newly diagnosed multiple myeloma (MM) patients. However, relapse is ubiquitous and therapy-related myeloid neoplasms (t-MN) post-ASCT are commonly associated with poor outcomes. We hypothesized that the enrichment of abnormal myeloid progenitors and immune effector cells (IEC) in the peripheral blood stem cells […]

Abstract Coagulation system activation is commonly observed in tumor patients, including prostate cancer (PCa), with coagulation markers proposed as potential prognostic indicators for cancer severity. However, the correlation between these markers and clinicopathological features in PCa remains unclear. Thus, this study investigates the association between comprehensive coagulation markers and clinicopathological characteristics in PCa patients. A […]

Importance  An estimated 15 000 children and adolescents aged 0 to 19 years are diagnosed with cancer each year in the US, and more than 85% survive for at least 5 years. By 45 years of age, approximately 95% of people who survive childhood cancer will develop a significant health problem related to the childhood cancer […]

Jan van de Winkel, PhD The European Commission (EC) has granted conditional marketing authorization to epcoritamab-bysp (Tepkinly) for use as a single agent in adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) following 2 or more lines of systemic treatment.1 Additionally, Japan’s Ministry of Health, Labour, and Welfare has approved the agent […]

As weird as it sounds, I already knew about the dinosaur park on Western’s campus but this Stonehenge replica was certainly news to me! How much do you know about it– if anything at all? I saw some photos posted on local Facebook group Vanished Kalamazoo and although the area pictured didn’t look very familiar to me, […]

Guillermo Garcia-Manero, MD Luspatercept-aamt (Reblozyl) is a novel addition to the transfusion-dependent, lower-risk myelodysplastic syndrome (MDS)–associated anemia armamentarium, particularly for patients with ring sideroblastic disease, according to Guillermo Garcia-Manero, MD. The phase 3 COMMANDS trial (NCT03682536) investigated luspatercept vs the erythropoiesis stimulating agent (ESA) epoetin alfa in ESA-naïve patients with transfusion-dependent, lower-risk MDS with anemia. […]

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An absence of information about the patterns of Salmonellosis in Latin America has been identified and an imperative need has arisen to generate population and clinical studies to evaluate disease dynamics, mortality and risk factors for severe disease [11, 19]. This study contributes to the generation of knowledge about clinical patterns, resistance, mortality and related […]