Abstract Colorectal carcinoma (CRC) is the third most common malignancy worldwide, and second in number of deaths in the world. The molecular pathogenesis of CRC is heterogeneous and can affect several genes. Moreover, genomic instability is recognized as an important part of CRC carcinogenesis and is tightly connected to DNA damage response. DNA damage repair […]
New York, USA, Sept. 25, 2023 (GLOBE NEWSWIRE) — Chronic Obstructive Pulmonary Disease Market to Witness Upsurge in Growth During the Forecast Period (2023–2032), Assesses DelveInsight | Key Companies – Genentech, GlaxoSmithKline, Regeneron, Sanofi, AstraZeneca, Mereo, Inmunotek The dynamics of the chronic obstructive pulmonary disease market are anticipated to change in the coming years owing […]
Samer A. Srour, MB, ChB, MS, assistant professor in the department of stem cell transplantation, division of cancer medicine at The University of Texas MD Anderson Cancer Center, discusses the design of ALLO-316, an agent investigated in the phase 2 TRAVERSE trial (NCT04696731) for patients with renal cell carcinoma (RCC). Chimeric antigen receptor (CAR) T-cell […]
Abstract The prognosis of renal cell carcinoma (RCC) malignant neoplasms deeply relies on an accurate determination of the histological subtype, which currently involves the light microscopy visual analysis of histological slides, considering notably tumor architecture and cytology. RCC subtyping is therefore a time-consuming and tedious process, sometimes requiring expert review, with great impact on diagnosis, […]
About 15% of lung-resections surgeries are performed on nodules that are actually benign, researchers estimated in a new study published in Clinical Imaging [1]. The specialty has made great strides in addressing this number. As recently as the mid-1990s, about half of such surgeries were conducted on benign nodules, a number that dropped to 20% […]
Germline genetic predisposition to myeloid neoplasms contributes to cytopenias and hypoplastic bone marrow (BM) in adult patients, and pathogenic/likely pathogenic genetic variants are associated with a higher risk of severe cytopenias and advanced myeloid neoplasms in this population, according to research published in Blood. Researchers evaluated the prevalence and phenotypic expressivity of germline variants predisposing […]
Aaron Gerds, MD, MS: The NCCN [National Comprehensive Cancer Network] guidelines for polycythemia vera and the other MPNs [myeloproliferative neoplasms] are updated regularly. So certainly there’s a large effort to annually update them, where we go over the entire sets of guidelines to update and refine them. But as new developments come along, we update […]
East Alabama Health’s Office of Clinical Research Thank you for your interest in East Alabama Health’s Office of Clinical Research. Our organization is dedicated to providing researchers the opportunity to improve patient care and outcomes within our community, our state, and on a national scale. We have a committed team of healthcare professionals here to work in collaboration […]
NPM1-mutated acute myeloid leukemia (AML) is the most common genetic type of adult AML (about 30%-35% of cases) [1] and, due to its distinctive molecular and clinico-pathological features [2, 3], is recognized as a new leukemia entity in the 2022 ICC [4] and WHO fifth edition [5] classifications of myeloid neoplasms. Two distinguishing biological characteristics […]
