Category Archives: Cancer and neoplasms

The acidic stretch and the C-terminal nuclear export signal motif of NPM1 mutant: are they druggable in AML?

NPM1-mutated acute myeloid leukemia (AML) is the most common genetic type of adult AML (about 30%-35% of cases) [1] and, due to its distinctive molecular and clinico-pathological features [2, 3], is recognized as a new leukemia entity in the 2022 ICC [4] and WHO fifth edition [5] classifications of myeloid neoplasms. Two distinguishing biological characteristics […]

Excitement Around Cilta-Cel in Multiple Myeloma

Yi Lin MD, PhD, a hematologist/oncologist, consultant, Division of Hematology, Department of Internal Medicine, enterprise leader, Cancer Regenerative Medicine, Biotherapeutics, and Biomanufacturing, Mayo Clinic Comprehensive Cancer Center, associate medical director, Center for Regenerative Biotherapeutics, and consultant, Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, discusses the impact of the phase […]

Exposure to All Pesticide Classes Increase Nervous System Tumor Risk

(Beyond Pesticides, September 21, 2023) A literature review published in Ciência & Saúde Coletiva finds environmental exposure to all classes of pesticides (fungicides, herbicides, insecticides) has an association with childhood astrocytoma (brain/central nervous system [CNS] tumor). CNS tumors represent half of all malignant neoplasms (tumors) in children. Although medical advancements in disease survival are progressing, childhood […]

Validation of the diagnostic efficacy of O-RADS in adnexal masses

Abstract The aim of this study was to validate the performance of the Ovarian-Adnexal Reporting and Data Systems (O-RADS) series models proposed by the American College of Radiology (ACR) in the preoperative diagnosis of adnexal masses (AMs). Two experienced sonologists examined 218 patients with AMs and gave the assessment results after the examination. Pathological findings […]