Category Archives: Cancer and neoplasms

Abstract Head and neck cancer (HNC) was the seventh most common cancer in the world in 2018. Treatment of a patient may include surgery, radiotherapy (RT), chemotherapy, targeted therapy, immunotherapy, or a combination of these methods. Ionizing radiation used during RT covers relatively large volumes of healthy tissue surrounding the tumor. The acute form of […]

Aaron T. Gerds, MD, MS The FDA approval of momelotinib (Ojjaara) has provided a potentially new standard-of-care treatment option for patients with myelofibrosis who have anemia, and according to Aaron T. Gerds, MD, MS, findings from the phase 3 MOMENTUM trial (NCT04173494) serve as the basis of this approval. In the international, randomized, double-blind, controlled […]

Combination sacituzumab govitecan-hziy (Trodelvy; Gilead) and pembrolizumab (Keytruda; Merck) showed promising early antitumor activity in patients with advanced or metastatic non­–small cell lung cancer (NSCLC) in the first-line setting, according to findings from the phase 2 EVOKE-02 trial (NCT05186974) announced in a press release and presented at the International Association for the Study of Lung […]

Warren C. Swegal, MD, a head and neck cancer surgeon at Allegheny Health Network, discusses the role of cabozantinib (Cabometyx) for patients with radioactive iodine (RAI)–refractory differentiated thyroid cancer (DTC). Cabozantinib is currently a second-line option for patients who have progressed on sorafenib (Nexavar) or lenvatinib (Lenvima) and are refractory or ineligible for RAI, based […]

Arlene O. Siefker-Radtke, MD According to Arlene O. Siefker-Radtke, MD, erdafitinib (Balversa) represents a potentially groundbreaking advancement for the treatment of metastatic urothelial carcinoma (mUC). Erdafitinib is an FGFR1-4 inhibitor being evaluated for the treatment of patients with urothelial cancer. As a pan-FGFR inhibitor, erdafitinib marks the first biomarker targeted therapy for patients with mUC. […]

Elcin Barker Ergun The European Commission has approved elacestrant (Orserdu) for the treatment of postmenopausal women and men with estrogen receptor (ER)–positive, HER2-negative, locally advanced, or metastatic breast cancer with an activating ESR1 mutation who have disease progression following at least 1 line of endocrine therapy including a CDK4/6 inhibitor.1 The approval was based on […]

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New York, USA, Sept. 20, 2023 (GLOBE NEWSWIRE) — Osteosarcoma Market to Grow Rapidly by 2032, Assesses DelveInsight | Leading Companies – MedPacto, Y-mAbs, QSAM, BioEclipse, Cellectar Biosciences, BioAtla, Salarius, Jazz, Fusion, Sumitomo Pharma Oncology The dynamics of the osteosarcoma market are anticipated to change in the coming years owing to the improvement in the […]

Abstract Acute myeloid leukemia (AML) is characterized by an unfavorable prognosis due to the presence of self-renewing leukemic stem cells (LSCs). The presence of T-cell immunoglobulin mucin-3 (TIM-3) on the surface of LSCs has been observed in various types of human AML, exerting an impact on the prognostic outcome. Exploring the hub genes associated with […]