Introduction Tuberculosis disease (TB) is a major public health problem and tops the list of causes of death in the world.1 95% of tuberculosis deaths occur in low-middle-income countries (LMICs), with two-thirds of deaths happening in 8 LMICs and Ethiopia is one of the top 22 counties affected by tuberculosis (TB)2 with a 2.1/1000 incidence […]
Introduction Polycythemia vera (PV) is a hematological disorder classified under myeloproliferative neoplasms (MPN) by the World Health Organization (WHO). Although there are seven subcategories under the MPN category, the term “MPN” is commonly reserved for the three pathological entities that lack the Philadelphia chromosome (Ph-) but carry mutations in the Janus kinase 2 (JAK2), calreticulin […]
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Abstract Few prognostic biomarkers exist for lung squamous cell carcinoma (LUSC), which has a poor five-year survival rate. Using bioinformatics, this study evaluated NPLOC4 as a prognostic marker for patients with lung squamous cell carcinoma. Shorter survival periods and tumor growth were linked to high NPLOC4 expression.Disulfiram (DSF) combined with copper (Cu) targets NPLOC4 to […]
Dublin, Nov. 22, 2023 (GLOBE NEWSWIRE) — The “TCR-Therapy – Pipeline Insight, 2023” drug pipelines has been added to ResearchAndMarkets.com’s offering. This report provides comprehensive insights about 30+ companies and 100+ pipeline drugs in TCR-Therapy pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment […]
Transmissible cancer affects marine bivalve mollusks worldwide, but how genetic mechanisms influence cancer evolution and disease spread remains largely unexplored. Two new studies provide insights into the ancient origin of founder clones and the long-term tolerance of contagious cancer cells to extreme genome instability. Two studies in this issue of Nature Cancer set out to […]
Momelotinib has been added to the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology for the treatment of patients with high- and low-risk myelofibrosis (MF) and myelofibrosis with anemia. Neoplasms, cancerous disease, malignant tumour | Ирина Батюк – stock.adobe.com MF is part of a group of heterogeneous disorders of the hematopoietic system collectively […]
Among a cohort of patients who received a flu vaccine, there was a 26% decreased risk of heart attacks and a 33% reduction in cardiovascular deaths, according to one study. These findings suggest a connection between influenza vaccination and reduced risk of cardiovascular diseases (CVDs). Hand holding vial with vaccine against corona virus | Thaut […]
red blood cells flowing realistic 3d rendering: © Kodjovi – stock.adobe.com The combination of pelabresib (CPI-0610), an investigational BET inhibitor, with the ruxolitinib (Jakafi), a JAK inhibitor, demonstrated a statistically significant and clinically meaningful improvement in the proportion of JAK inhibitor-naive patients with myelofibrosis (MF) achieving at least a 35% reduction in spleen volume (SVR35) […]
Physicians and scientists from Fred Hutch and UW Medicine are testing new treatments for liver cancer and discovering new ways to use current liver cancer treatments. Through this work, we are looking for answers to two main questions: How can we do even better at controlling or curing liver cancer? How can we make treatments […]