Abstract Early detection of cancer is vital for the best chance of successful treatment, but half of all cancers are diagnosed at an advanced stage. A simple and reliable blood screening test applied routinely would therefore address a major unmet medical need. To gain insight into the value of protein biomarkers in early detection and […]
Abstract Despite being considered a single disease, Diffuse Large B Cell Lymphoma (DLBCL) presents with variable backgrounds, which results in heterogeneous outcomes among patients, with 40% of them still having primary refractory disease or relapse. Thus, novel biomarkers are needed. In addition, multiple factors regarding its pathogenesis remain unclear. In this context, recent investigations point […]
A polygenic risk score can predict the risk of second malignant neoplasms (SMNs) in pediatric cancer survivors who were treated with chemotherapy, according to research published in the Journal of Clinical Oncology. The 179-variant score, which was previously validated in adults, “has strong potential for improving SMN clinical risk stratification among nonirradiated [pediatric cancer] […]
— Conference Call Scheduled for Wednesday, August 2, 2023, at 8:00 a.m. ET — NEWTON, Mass., July 26, 2023 /PRNewswire/ — Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced it will report second quarter 2023 financial results on Wednesday, August 2, 2023. Karyopharm’s management team will host a […]
The global Hematologic Malignancies Testing Market had a size of USD 2.55 billion in 2021 and is expected to grow at a CAGR of 14.7% during the forecast period. Hematologic malignancies are cancers that develop in blood, bone marrow, and lymph nodes. The rising prevalence of blood cancer, leukemia, and multiple myeloma worldwide, increasing healthcare […]
Abstract Currently, treatment allocation of patients with Mantle Cell Lymphoma (MCL) is mainly based on age and medical fitness. The combined MCL International Prognostic Index (MIPI-c) allows to predict prognosis using clinical factors (MIPI) and the Ki-67 index. However, high p53 expression as surrogate for TP53 alterations has demonstrated to be an independent predictor for […]
Abstract Recent studies have documented frequent evolution of clones carrying common cancer mutations in apparently normal tissues, which are implicated in cancer development1,2,3. However, our knowledge is still missing with regard to what additional driver events take place in what order, before one or more of these clones in normal tissues ultimately evolve to cancer. […]
Identification and description of the studies One hundred and two studies were included in this meta-analysis. Forty eight studies reported an association between obesity and breast cancer in pre-menopausal women, and 67 studies showed a relationship between obesity and breast cancer in post-menopausal women. 34 studies (4 cross-sectional,18 case–control, and 12 cohort) with a total […]
