Dydrogesterone use during early pregnancy was associated with increased reporting of birth defects, including congenital heart defects and hypospadias, a global pharmacovigilance study that examined approximately 30 million birth records reported. The study was published in ‘Human Reproduction-Oxford Academic’ Journal. This pharmacovigilance study, designed as a case–non-case study, analyzed 29,120,563 individual case safety reports using […]
Category Archives: Congenital disorders
Dydrogesterone use during early pregnancy was associated with increased reporting of birth defects, including congenital heart defects and hypospadias, a global pharmacovigilance study that examined approximately 30 million birth records reported. The study was published in ‘Human Reproduction-Oxford Academic’ Journal. This pharmacovigilance study, designed as a case–non-case study, analyzed 29,120,563 individual case safety reports using […]
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Introduction Why is obstetrical surgery important for reproductive health morbidity care in 2023? What are the systems (primary/secondary) and clinical factors that create morbidity for pregnant people? What evidenced-based management tools and implemented processes can be considered or used to provide enhanced safety and quality for obstetrical surgery? The rates of caesarean delivery (CD) and […]
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As far as the archivist knew, the 48 box files locked in an attic above the Institute for the History of Medicine at the University of Bern had never been opened. They contained a mass of handwritten letters, glass-plate negatives, annotated offprints, minutes of meetings, and piles of press clippings almost too fragile to touch. […]
Abstract SLC5A6 encodes the sodium-dependent multivitamin transporter, a transmembrane protein that uptakes biotin, pantothenic acid, and lipoic acid. Biallelic SLC5A6 variants cause sodium-dependent multivitamin transporter deficiency (SMVTD) and childhood-onset biotin-responsive peripheral motor neuropathy (COMNB), which both respond well to replacement therapy with the above three nutrients. SMVTD usually presents with various symptoms in multiple organs, […]
The treatments included a number of chronic health conditions including chronic pain, severe IBS, sleep disorders, and neurological conditions like Parkinson’s, epilepsy, and motor neurone disease. This decision marked the legalization of medical cannabis in the UK. Releaf, the UK’s first all-in-one medical cannabis e-clinic has taken a look at the industry’s progress with the […]
Congenital disorders
The effects of zinc supplementation on the metabolic factors in patients with non-alcoholic fatty liver disease: a randomized, double-blinded, placebo-controlled clinical trial
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This 8-week clinical trial investigated the effects of Zn supplementation on the Zn status, liver aminotransferases, anthropometric variables, glycemic indices, lipid profile, and some inflammation and oxidative stress parameters in patients with NAFLD. According to the between-group comparison, consuming 30 mg/d Zn had a significant effect on the Zn status, anthropometric parameters, AST, TC, and LDL-C, […]
Whether death occurs in the context of a chronic illness or as the sudden loss of a previously healthy infant, child, or adolescent, the death of a child is a highly stressful and traumatic event. Psychosocial support for families after the death of a child embodies core medical values of professional fidelity, compassion, respect for […]
Congenital disorders
Erythema multiforme major associated with SARS-CoV-2 infection in a patient with skin of colour
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A 38-year-old man with Fitzpatrick type V skin presented to the emergency department with a 2-week history of fever, productive cough, rhinorrhea and 5 days of oral pain. He was otherwise healthy and took no medications. He had been vaccinated against SARS-CoV-2, but SARS-CoV-2 infection was suspected and confirmed with a nasopharyngeal swab. Examination revealed […]
Congenital disorders
Time to improve transparency at Health Canada’s Pest Management Regulatory Agency
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KEY POINTS In the last year, Health Canada’s Pest Management Regulatory Agency has been criticized for not releasing information about the safety of pesticides because data are considered confidential business information. This level of secrecy contrasts with Health Canada’s efforts to improve transparency related to therapeutic products. Vanessa’s Law gives the federal Minister of Health […]