Bryan Christie Edinburgh Between 95 000 and 167 000 patients are estimated to have caught covid-19 in England’s hospitals during the second wave of the pandemic while being treated for other problems. A study reported in Nature used data from 356 English hospitals, representing almost all NHS general and acute care beds, to calculate the extent of […]
Abstract Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we show that Calpeptin is an extremely potent cysteine cathepsin inhibitor, a finding additionally supported by X-ray crystallography. Cell infection […]
Abstract The pork industry is an essential part of the global food system, providing a significant source of protein for people around the world. A major factor restraining productivity and compromising animal wellbeing in the pork industry is disease outbreaks in pigs throughout the production process: widespread outbreaks can lead to losses as high as […]
Abstract Japan implemented its nationwide vaccination program against COVID-19 in 2021, immunizing more than one million people (approximately 1%) a day. However, the direct and indirect impacts of the program at the population level have yet to be fully evaluated. To assess the vaccine effectiveness during the Delta variant (B.1.617.2) epidemic in 2021, we used […]
Adding vancomycin to beta-lactam prophylaxis with cefazolin did not help prevent surgical-site infections in patients undergoing arthroplasty mostly for the knees or hips, a randomized trial showed. In over 4,000 patients without known methicillin-resistant Staphylococcus aureus (MRSA) colonization, surgical-site infections at 90 days occurred in 4.5% of those who received the combination compared with 3.5% […]
In recent weeks, the news of American gymnast Mary Lou Retton’s hospitalization for a rare type of pneumonia raises the question of what the major risks are for developing the condition. Pneumonia is the world’s leading cause of death for children under the age of five, and the leading cause of hospitalization for adults in […]
Abstract Hospital-based transmission had a dominant role in Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) epidemics1,2, but large-scale studies of its role in the SARS-CoV-2 pandemic are lacking. Such transmission risks spreading the virus to the most vulnerable individuals and can have wider-scale impacts through hospital–community interactions. Using data […]
York Region is reminding residents to be aware of disease spread as it marks National Infection Control Week Oct. 16 to 20. York Region Public Health is encouraging everyone to protect themselves and their loved ones as the Ontario respiratory illness season hits, with cases of COVID-19, influenza and respiratory syncytial virus (RSV) increasing. Public […]
Recently, a nurse posted a video on TikTok saying she had a patient who got a staph infection from their smartwatch and she reminded viewers to clean theirs. CLEVELAND — Since smartwatches and fitness watches hit the market, many have learned the hard way that they have to be routinely cleaned, especially for those who […]
Palestinians look for survivors of the Israeli bombardment of Rafah, southern Gaza Strip, Oct. 17, 2023. (Hatem Ali / AP Photo) The situation in the Gaza Strip is dire. Amidst an intense bombing campaign, Israel has shut off water and power and limited essential supplies such as food, medicine and fuel, creating a massive public […]