Category Archives: Infection

CAR T cell therapies may lead to reactivation of childhood viral infections

<div data-thumb="https://scx1.b-cdn.net/csz/news/tmb/2023/car-t-cell-therapies-m.jpg" data-src="https://scx2.b-cdn.net/gfx/news/hires/2023/car-t-cell-therapies-m.jpg" data-sub-html="Petabase-scale analysis of viral nucleic acids reveals that HHV-6 is reactivated in human T cells. a, Schematic of life cycles of endogenous human viruses. Viruses can enter a latent phase after primary infection and become reactivated following environmental cues, including drugs, immunization and other infections. b, Enumeration of BioSamples with human viruses showing […]

Dengue fever sweeps through Asia, helped by hotter and wetter weather

BANGKOK/HANOI/TAIPEI — Dengue fever infections are surging across large swaths of Asia, spurred by climate change and unusually rainy weather, with Bangladesh’s death toll this year exceeding 1,000. Infections are up roughly 200% on the year in Thailand and Cambodia, while Taiwan is seeing a rapid surge. The outbreaks could affect their economic recoveries from […]

Q&A: Infections from over-the-counter artificial tears—implications for patients and clinicians

Credit: Unsplash/CC0 Public Domain The Food and Drug Administration (FDA) has recalled dozens of over-the-counter eye drops—artificial tears—in 2023 due to contamination and unsafe manufacturing practices. Four deaths from sepsis, 14 cases of vision loss and more than 80 infections were reported as of May. Most of the patients reported using EzriCare Artificial Tears, which […]

Next steps for PCR testing for urinary tract infection

In this video, Roger R. Dmochowski, MD, MMHC, FACS, describes the next steps for PCR testing for urinary tract infection. He is senior author of the Neurology and Urodynamics study “Recurrent and complicated urinary tract infections in women: Utility of advanced testing to enhance care.” Dmochowski is professor of urology, surgery and gynecology and vice […]

How tiny hinges bend the infection-spreading spikes of a coronavirus

<div data-thumb="https://scx1.b-cdn.net/csz/news/tmb/2023/how-tiny-hinges-bend-t.jpg" data-src="https://scx2.b-cdn.net/gfx/news/hires/2023/how-tiny-hinges-bend-t.jpg" data-sub-html="CryoET of HCoV-NL63 intact virions. A Tomogram slice of HCoV-NL63 virions embedded in vitreous ice. B Subtomogram average of prefusion spike crown at 6.9 Å resolution. Density map is displayed from the side view (top) and top view (bottom), with the density of one S protomer colored (blue) and RBD (red circle) and […]

HIV Infection Could Affect Individual’s IQ Score

HIV infection could have a negative influence on an individual’s IQ score and gut microbiome based on differences in a patient’s neurons, according to a review published in Frontiers in Behavioral Neuroscience. HIV infections, although efficiently suppressed through antiretroviral therapy (ART), are still spreading without a cure throughout the world. HIV is known to affect […]

The Impact of Rebound Infections with Paxlovid: Exploring the Risk and Potential Solutions

A new study led by Dr. Mark Siedner, published in the Annals of Internal Medicine, sheds light on the rebound effect of Paxlovid, a popular antiviral treatment for COVID-19. While Pfizer initially reported a low occurrence rate of rebound, around 2.3%, subsequent studies have shown higher rates, up to 14%. Siedner’s study aimed to specifically […]

Newly identified SARS-CoV-2 infection pathway provides clues to severe COVID-19 cases and obesity link

<div data-thumb="https://scx1.b-cdn.net/csz/news/tmb/2023/newly-identified-sars.jpg" data-src="https://scx2.b-cdn.net/gfx/news/hires/2023/newly-identified-sars.jpg" data-sub-html="The 3′-end of SARS-CoV-2 genome bears an inducible RNA element. a Positive (+) strand SARS-CoV-2 genome is transcribed into nested subgenomic (sg) RNAs, all containing identical 5′-leaders and 3′-ends; schematic adapted with permission9. b Top: schematic of sgRNA reporter with SARS-CoV-2 5′-leader and 3′-end. Bottom: Effect of agonists on sgRNA reporter expression. […]

Rebound Infections Occur in 20% of Paxlovid Users

COVID-19 has become less of an urgent threat than it was in 2019 largely because of vaccines and growing immunity from natural infections, but antiviral treatments have also changed the course of the disease. The most popular of these is nirmatrelvir-ritonavir, sold under the brand name Paxlovid, which the U.S. Centers for Disease Control and […]