Cellular state landscape and herpes simplex virus type 1 infection progression are connected

Abstract Prediction, prevention and treatment of virus infections require understanding of cell-to-cell variability that leads to heterogenous disease outcomes, but the source of this heterogeneity has yet to be clarified. To study the multimodal response of single human cells to herpes simplex virus type 1 (HSV-1) infection, we mapped high-dimensional viral and cellular state spaces […]

Metabolic systems approaches update molecular insights of clinical phenotypes and cardiovascular risk in patients with homozygous familial hypercholesterolemia

Demographic and clinical characteristics of all participants A total of 660 individuals participated in the discovery cross-sectional study (Fig. 1a), including 184 genetically confirmed HoFH patients (male, 50.1%), 376 HeFH patients (male, 49.2%), and 100 non-FH individuals (male, 53.0%). The clinical characteristics of the study individuals are presented in Table 1. Patients with HoFH had higher […]

microRNA sequencing for biomarker detection in the diagnosis, classification and prognosis of Diffuse Large B Cell Lymphoma

Abstract Despite being considered a single disease, Diffuse Large B Cell Lymphoma (DLBCL) presents with variable backgrounds, which results in heterogeneous outcomes among patients, with 40% of them still having primary refractory disease or relapse. Thus, novel biomarkers are needed. In addition, multiple factors regarding its pathogenesis remain unclear. In this context, recent investigations point […]

Phenotypes, cardiovascular disease . . . and other stories

Genome-wide association studies of cardiovascular disease According to the NHGRI-EBI catalogue of human genome-wide association studies (https://www.ebi.ac.uk/gwas), 1700 studies have been performed on phenotypes related to common cardiovascular diseases, such as coronary artery disease, atrial fibrillation, stroke, and hypertension. Hundreds of genomic loci associated with these phenotypes have been identified. Although polygenic scores that summarise […]

Nasal swab test could be breakthrough for children with suspected sinus infections

Test could be breakthrough for children with suspected sinus infections Test could be breakthrough for children with suspected sinus infections 02:53 PITTSBURGH (KDKA) — A nasal swab test could be a breakthrough for children with suspected sinus infections.  The test could tell parents whether their child needs antibiotics for their sinus infection or not.  Melissa […]

Coastal Bend Blood Center looking for heroes

CORPUS CHRISTI, Tx — The Coastal Bend Blood Center held its first school blood drive of the new school year. Their blood mobile was at the London School district on Wednesday to launch the center’s “High School Heroes” campaign. High school students account for 30% of the Coastal Bend Blood Center’s supply. Students like London […]

54 lives saved from Collier blood drive

<img width="840" height="486" src="https://medicalguru.us/wp-content/uploads/2023/07/blood-drive-collier.jpg" class="skip-lazy wp-post-image" alt decoding="async" data-attachment-id="365173" data-permalink="https://winknews.com/2023/07/26/community-blood-center-blood-drive-collier/blood-drive-collier/" data-orig-file="https://winknews.com/wp-content/uploads/2023/07/blood-drive-collier.jpg" data-orig-size="1026,577" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="blood drive collier" data-image-description data-image-caption=" Flyer for Collier blood drive CREDIT Collier County Sheriff’s Office ” data-medium-file=”https://winknews.com/wp-content/uploads/2023/07/blood-drive-collier.jpg?w=300″ data-large-file=”https://winknews.com/wp-content/uploads/2023/07/blood-drive-collier.jpg?w=1024″>Flyer for Collier blood drive CREDIT Collier County Sheriff’s Office NCH’s Community Blood Center ran a blood drive where enough blood was collected to […]

FDA Approves Blood Thinner Reversal Drug, But Requires More Tests to Assess Serious Risk

An Octapharma drug already sold in Europe and Canada for reversing the effects of blood-thinning medicines in patients undergoing emergency surgery or invasive procedures is now approved for use in the U.S. However, more complications and fatalities were observed in the study drug group, so as a condition of approval the FDA is requiring Octapharma […]

Tori Kelly’s husband says she is ‘smiling and feeling stronger’ after blood-clot scare

Tori Kelly’s husband provided an update Wednesday on her condition after the singer reportedly lost consciousness and was rushed to the hospital with blood clots this week. Basketball player André Murillo, who married Kelly in 2018, said on his Instagram story that the “I Was Made for Loving You” artist “is smiling and feeling stronger,” […]