Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of antibiotic-associated diarrhea worldwide? In a new paper published in Science Advances, researchers at Children’s Hospital of Philadelphia (CHOP) have begun to answer that question, showing that NSAIDs disrupt the mitochondria of cells lining the colon, sensitizing them to damage […]
CHRISTUS St. Michael Health System is joining with Carter BloodCare to meet the needs of local patients and donors with upcoming blood drives scheduled for Aug. 2. “Partnering with such a well-known, established brand like Carter BloodCare will allow us to reach a larger donor pool and expand our services across the region,” said Jessica […]
A Texas mother is accused of subjecting her 3-year-old daughter to medical child abuse and lying to medical staff at various hospitals in an alleged case of Munchausen syndrome by proxy, according to court documents obtained by multiple news outlets. Jessica Gasser, 27, allegedly had multiple “unnecessary medical procedures” performed on her child for an […]
What Question Were You Investigating? Ovarian cancer is the fourth leading cause of cancer mortality amongst women and is characterized by late detection, extensive metastasis and poor prognosis. One the reasons that treating this disease has been so challenging is that tumors often become resistant to chemotherapies, and generally respond poorly to immunotherapies. While much […]
“Don’t eat me!” That’s how one might translate the signal that the cancer cells in a glioblastoma send to the macrophages (white blood cells specialized in removing dead and dying cellular matter) in the brain. Immunotherapy attempts to enable these cells to eradicate the abnormal cells, but so far, it has met with little success […]
A medical illustration of Clostridioides difficile bacteria, formerly known as Clostridium difficile, presented in the Centers for Disease Control and Prevention (CDC) publication entitled, Antibiotic Resistance Threats in the United States, 2019. Credit: CDC Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of antibiotic-associated diarrhea worldwide? In a […]
Lenvatinib (Lenvima) with pembrolizumab (Keytruda) elicited higher, more durable responses and improved survival outcomes compared with sunitinib (Sutent) in the treatment of patients with advanced renal cell carcinoma (RCC), according to findings from the phase 3 CLEAR study (NCT02811861). In data presented at the 2023 Kidney Cancer Research Summit, the objective response rate (ORR) was […]
Patrick T. Ellinor, MD, PhD Credit: Massachusetts General Hospital A “weekend warrior” physical activity pattern, meaning most moderate to vigorous activity was achieved over 1 to 2 days, was associated with a similarly lower risk of cardiovascular outcomes as evenly distributed activity, according to new research.1 The analysis of nearly 90,000 individuals providing a week […]
–Study shows that NSAIDs disrupt epithelial cells in the colon and sensitize them to C. difficile toxins by perturbing cell mitochondria— PHILADELPHIA, July 19, 2023 /PRNewswire/ — Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of antibiotic-associated diarrhea worldwide? In a new paper published in Science Advances, researchers at […]
Have you ever wondered why some people never became sick from COVID-19? A study published today in Nature shows that common genetic variation among people is responsible for mediating SARS-CoV-2 asymptomatic infection. The results indicate that individuals having this variant never feel sick once infected. This exciting discovery was a result of a U.S.-Australia collaborative […]