Cancer and neoplasms
Artificial intelligence-powered spatial analysis of tumor-infiltrating lymphocytes for prediction of prognosis in resected colon cancer
Nov
Abstract Tumor-infiltrating lymphocytes (TIL) have been suggested as an important prognostic marker in colorectal cancer, but assessment usually requires additional tissue processing and interpretational efforts. The aim of this study is to assess the clinical significance of artificial intelligence (AI)-powered spatial TIL analysis using only a hematoxylin and eosin (H&E)-stained whole-slide image (WSI) for the […]
Nov
Protein indicators of subclinical peripheral heath in plasma were linked with markers of Alzheimer’s disease and neurodegeneration, cross-sectional proteomic analyses showed. Greater protein-based risk for cardiovascular disease, heart failure mortality, and kidney disease was associated with plasma biomarkers of amyloid-beta, phosphorylated tau181 (p-tau181), neurofilament light (NfL, a measure of neuronal injury), and glial fibrillary acidic […]
Cancer and neoplasms
Is there a role for radical prostatectomy in the management of oligometastatic prostate cancer? A systematic review
Nov
Abstract Context: There is a growing interest about the role of radical prostatectomy (RP) in local cancer control in oligometastatic prostate cancer (PCa). Purpose: To evaluate the oncological and functional outcomes of RP in the management of oligometastatic PCa through a systematic review. Methods: A systematic review search was performed and the following bibliographic databases […]
Infection
Blood plasma metagenomic next-generation sequencing for identifying pathogens of febrile neutropenia in acute leukemia patients
Nov
Abstract To investigate the value of metagenomic next-generation sequencing (mNGS) in acute leukemia (AL) patients with febrile neutropenia (FN). We retrospectively reviewed 37 AL patients with FN and compared the results of mNGS with blood culture (BC) and the clinical features of the mNGS-positive group and the mNGS-negative group. A total of 14 detected pathogens […]
Cardiovascular
Once-weekly glucagon-like peptide-1 receptor agonists vs dipeptidyl peptidase-4 inhibitors: cardiovascular effects in people with diabetes and cardiovascular disease
Nov
Study design This was an observational cohort study using the Optum Clinformatics® Data Mart (CDM) database to compare cardiovascular outcomes in adults with T2D and established ASCVD who initiated a OW GLP-1 RA or a DPP-4i. The study period was from January 1, 2017, to September 30, 2021. ASCVD history was examined back to 2001. […]
Nov
Jeanette Erdmann, professor of human genetics at the University of Lübeck and the German Center for Cardiovascular Research (DZHK), sadly passed away on 9 July 2023 at the age of 57. We grieve the loss of an extraordinary woman who embraced her scientific profession with unwavering dedication, contributing to groundbreaking work in the field of […]