Abstract Persistent symptoms following the acute phase of COVID-19 present a major burden to both the affected and the wider community. We conducted a cohort study including over 856,840 first COVID-19 cases, 72,422 re-infections and more than 3.1 million first negative-test controls from primary care electronic health records from Spain and the UK (Sept 2020 […]

Our study at a large London tertiary hospital during the first wave of the UK epidemic found that 84.7% of patients with severe COVID-19 received antimicrobial therapy, despite only 13.3% developing a microbiologically confirmed bacterial or fungal infection. The majority of infections were hospital-acquired, secondary infections with Gram-negative organisms. In those who received immunosuppressive therapy […]

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Senescent cells in the brain contribute to age-related neurodegeneration. Analysis of SARS-CoV-2 infection in human brain organoids, animals and post-mortem brain samples from patients with COVID-19 reveals virus-induced senescence. Pharmacological senolytic treatment following SARS-CoV-2 infection improves COVID-19 neuropathology and could help to protect people from long COVID. This is a preview of subscription content, access […]

The study population The data were extracted from the SARS-CoV-2 infection surveillance system in South Kivu (DRC) during the 2020 pandemic. The population of South Kivu is approximately 4,800,000 people who live in a 64,492 km² area. The study considered the first thousand alert cases recorded between March 29 and November 29, 2020. An alert case […]