Proline metabolism aids fungal virulence by visualizing infections deep in living host tissue.

Newswise — An international team of scientists led by researchers from the Department of Molecular Biosciences, The Wenner-Gren Institute, SciLifeLab, Stockholm University has published in PLoS Pathogens the first successful application of 2-photon intravital microscopy (IVM) to image the dynamics of fungal infections in the kidney of a living host. The study reveals that the opportunistic human […]

Tuberculosis Testing and Latent Tuberculosis Infection

Summary What is already known about this topic? CDC recommends testing persons at increased risk for tuberculosis (TB) infection as part of routine health care using TB blood tests, when possible, and if a diagnosis of latent TB infection (LTBI) is made, prescribing a short-course treatment regimen. In 2022, approximately three quarters of reported U.S. […]

Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women

Key Points Question  Are posttraumatic stress disorder (PTSD) symptoms associated with poorer cardiovascular and neurocognitive health among midlife women, and do these associations vary by APOEε4 status? Findings  In this cross-sectional study of 274 midlife women, women with higher PTSD symptoms had significantly greater carotid atherosclerosis. Among women who were carriers of the APOEε4 genotype, […]

Potent antibodies have surprise source: people with chronic infections

.readcube-buybox { display: none !important;} Antibodies from people chronically infected with the bacterium Pseudomonas aeruginosa could be a useful treatment for the dangerous pathogen, a study in mice suggests1. 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Analysis of respiratory virus detection in hospitalized children with acute respiratory infection during the COVID-19 pandemic

General clinical features Among the cohort of 9782 children diagnosed with ARIs, 5021 cases (51.3%) were identified prior to the onset of the COVID-19 pandemic (2018–2019), while 4761 cases (48.7%) were diagnosed during the pandemic period (2020–2022). Compared with the pre-COVID, the proportion of children aged 0 ~ < 1 years on ARIs was lower during the COVID-19 […]

Human papillomavirus infections among women with cervical lesions and cervical cancer in Yueyang, China: a cross-sectional study of 3674 women from 2019 to 2022

HPV distribution characteristics in patients with cervical lesions Of the 3674 patients with cervical lesions, 2744 were positive for HPV, giving a prevalence of 74.69% (95% CI 73.28–76.09%). The prevalence of HPV in CIN I, CIN II, CIN III, and ICC groups were 66.65% (1273/1910, 95% CI 64.53–68.77%), 80.78% (580/718, 95% CI 77.89–83.67%), 83.88% (483/576, […]

The efficacy and safety assessment of oncolytic virotherapies in the treatment of advanced melanoma: a systematic review and meta-analysis

Galluzzi L, Humeau J, Buqué A, Zitvogel L, Kroemer G. Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors. Nat Rev Clin Oncol. 2020;17:725–41. https://doi.org/10.1038/s41571-020-0413-z. Article  PubMed  Google Scholar  Carlino MS, Larkin J, Long GV. Immune checkpoint inhibitors in melanoma. The Lancet. 2021;398:1002–14. https://doi.org/10.1016/S0140-6736(21)01206-X. Article  CAS  Google Scholar  Bagchi S, Yuan R, Engleman EG. […]