Infection
Association between levels of receptor binding domain antibodies of SARS-CoV-2, receipt of booster and risk of breakthrough infections: LA pandemic surveillance cohort study
Nov
Abstract Prevention of COVID-19 with vaccine requires multiple doses and updated boosters to maintain protection; however currently there are no tests that can measure immunity and guide clinical decisions about timing of booster doses. This study examined the association between the risk of COVID-19 breakthrough infections and receptor binding domain (RBD) antibody levels and receipt […]
Infection
COVID 19 infection clinical features in pediatric patients in Southwestern Iran: a cross-sectional, multi-center study
Nov
This study assessed the presence of SARS-CoV-2 infection rate using Taq man real-time PCR assay and the epidemiological and clinical data of them, in the southwest of Iran during 17 months of post-pandemic period. The mean age of infected patients was 5.71 years that is consistent with Dong et al.’s study [8]. Global data shows mixed […]
Blood
Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis
Nov
Abstract Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of LC patients represents a source of potential LC biomarkers. We compared expression of > 60,000 genes in whole blood specimens taken from […]
Cardiovascular
Impacts of COVID-19 pandemic through decomposition of life expectancy according to leading causes and place of death in Czechia
Nov
Abstract While the direct effects of the pandemic are well documented, less is known about the indirect ones, including changes in healthcare provision or human behavior. This paper aims to study the impact of indirect consequences on mortality, focusing on two leading causes (cardiovascular diseases, COVID-19) and places of death in Czechia, during the COVID-19 […]
Infection
Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infection
Nov
Abstract Clinical immunity against Plasmodium falciparum infection develops in residents of malaria endemic regions, manifesting in reduced clinical symptoms during infection and in protection against severe disease but the mechanisms are not fully understood. Here, we compare the cellular and humoral immune response of clinically immune (0-1 episode over 18 months) and susceptible (at least […]
Cancer and neoplasms
Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis
Nov
Abstract Current therapies for myeloproliferative neoplasms (MPNs) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem/progenitor cells (HSPCs). TAMARIN Phase-II, multicenter, single-arm clinical trial assessed tamoxifen’s safety and activity in patients with stable MPNs, no prior thrombotic events and mutated JAK2V617F, CALRins5 or CALRdel52 […]
Cardiovascular
An explainable machine learning-based phenomapping strategy for adaptive predictive enrichment in randomized clinical trials
Nov
Abstract Randomized clinical trials (RCT) represent the cornerstone of evidence-based medicine but are resource-intensive. We propose and evaluate a machine learning (ML) strategy of adaptive predictive enrichment through computational trial phenomaps to optimize RCT enrollment. In simulated group sequential analyses of two large cardiovascular outcomes RCTs of (1) a therapeutic drug (pioglitazone versus placebo; Insulin […]
Nov
Kawasaki disease, of yet-unknown causes, has seen a sharp decrease since the spread of the novel coronavirus. (Mainichi) TOKYO — Since the coronavirus pandemic began, the number of young children affected by Kawasaki disease in Japan has sharply declined, according to a nonprofit agency that studies the mysterious illness. The disease, discovered by Tomisaku Kawasaki […]